Advances in the Chemistry, Pharmacological Diversity, and Metabolism of 20()-ginseng Saponins

Overview

Journal J Ginseng Res

Date 2020 Feb 26

PMID 32095093

Citations 11

Authors

Chaoming Wang

Juan Liu

Jianqiang Deng

Jiazhen Wang

Weizhao Weng

Hongxia Chu

Qingguo Meng

Affiliations

Soon will be listed here.

Abstract

Ginseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20()-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20()-ginseng saponins are generally prepared by chemical epimerization and microbial transformation from 20()-isomers. The C20 configuration of 20()-ginseng saponins are usually determined by C NMR and X-ray single-crystal diffraction. 20()-ginseng saponins have antitumor, antioxidative, antifatigue, neuroprotective, and osteoclastogenesis inhibitory effects, among others. Owing to the chemical structure and pharmacological and stereoselective properties, 20()-ginseng saponins have attracted a great deal of attention in recent years. In this study, the discovery, identification, chemical epimerization, microbial transformation, pharmacological activities, and metabolism of 20()-ginseng saponins are summarized.

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