Uric Acid and Arterial Stiffness

Overview

Journal Ther Clin Risk Manag

Publisher Dove Medical Press

Date 2020 Feb 26

PMID 32095074

Citations 22

Authors

Adriana Albu

Ioana Para

Mihai Porojan

Affiliations

Soon will be listed here.

Abstract

Hyperuricemia is usually associated with hypertension, diabetes mellitus, metabolic syndrome and chronic kidney disease. Accumulating data from epidemiological studies indicate an association of increased uric acid (UA) with cardiovascular diseases. Possible pathogenic mechanisms include enhancement of oxidative stress and systemic inflammation caused by hyperuricemia. Arterial stiffness may be one of the possible pathways between hyperuricemia and cardiovascular disease, but a clear relationship between increased UA and vascular alterations has not been confirmed. The review summarizes the epidemiological studies investigating the relationship between UA and arterial stiffness and highlights the results of interventional studies evaluating arterial stiffness parameters in patients treated with UA-lowering drugs.

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