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Kampō Medicine and Muro Disease (Amyotrophic Lateral Sclerosis and Parkinsonism-Dementia Complex)

Overview
Journal eNeurologicalSci
Specialty Neurology
Date 2020 Feb 25
PMID 32090178
Citations 8
Authors
Peter S Spencer
Valerie S Palmer
Tameko Kihira
Sohei Yoshida
Jacques Reis
Momoko Yabushita
Yoshiro Yase
Affiliations
Soon will be listed here.
Abstract

Western Pacific Amyotrophic Lateral Sclerosis and Parkinsonism-dementia Complex (ALS/PDC) is a disappearing neurodegenerative disease in three former high-incidence foci of Guam-USA, Papua-Indonesia and Kii Peninsula, Honshu Island, Japan. The latter includes two distinct ALS/PDC-affected regions (Hohara and Kozagawa), where the disorder is known as Muro disease. In Hohara, oral exposure to plant (cycad) neurotoxins used in traditional medical practice has been linked previously to Muro disease. We report new observations that link Kampō medicine to Muro disease in the southern Kozagawa focus. Oral exposure to cycad seed toxins is associated with all three foci of Western Pacific ALS/PDC.

Citing Articles

Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders.

Kisby G, Wilson 3rd D, Spencer P Int J Mol Sci. 2024; 25(13).

PMID: 39000326 PMC: 11241460. DOI: 10.3390/ijms25137221.

Endemic parkinsonism: clusters, biology and clinical features.

Mensikova K, Steele J, Rosales R, Colosimo C, Spencer P, Lannuzel A Nat Rev Neurol. 2023; 19(10):599-616.

PMID: 37684518 DOI: 10.1038/s41582-023-00866-3.

Mycotoxins and Amyotrophic Lateral Sclerosis: Food Exposure, Nutritional Implications and Dietary Solutions.

Manera U, Matteoni E, Canosa A, Callegaro S, Casale F, Marchis D CNS Neurol Disord Drug Targets. 2023; 23(5):562-572.

PMID: 37592793 DOI: 10.2174/1871527323666230817145434.

Genotoxic Damage During Brain Development Presages Prototypical Neurodegenerative Disease.

Kisby G, Spencer P Front Neurosci. 2021; 15:752153.

PMID: 34924930 PMC: 8675606. DOI: 10.3389/fnins.2021.752153.

Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC.

Kisby G, Eriksen J, Chlebowski A, Spencer P J Neuropathol Exp Neurol. 2021; 80(3):286-288.

PMID: 33550390 PMC: 8786491. DOI: 10.1093/jnen/nlab006.

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