The Use of Antibiotic Impregnated Cement Spacers in the Treatment of Infected Total Joint Replacement: Challenges and Achievements

Overview

Journal Arch Bone Jt Surg

Date 2020 Feb 25

PMID 32090140

Citations 18

Authors

Omid Shahpari

Alireza Mousavian

Nafise Elahpour

Michael-Alexander Malahias

Mohammad H Ebrahimzadeh

Ali Moradi

Affiliations

Soon will be listed here.

Abstract

Two stage total hip arthroplasty revision surgery includes foreign material debridment, insertion of antibiotic impregnated cement spacer, and finally, reimplantation of the prosthesis. This review has aimed to evaluate the efficacy of antibiotic impregnated cement spacers in infection control and eradication in arthroplasties. A total of 85 articles on total hip arthroplasty were used in this narrative literature review. High concentrations of the antibiotic in targeted drug delivery by means of using antibiotic impregnated cement spacers is effective against infections while reduces the side effects of systemic antibiotic therapy. This results in prevention of bone and muscle atrophy as well as size discrepancy. Also, antibiotic impregnated cement spacers reduce dead space and help stabilize the limb in total hip arthroplasty. Despite all reported drawbacks, antibiotic impregnated cement spacers seem effective in eradicationg infections, although a consensus has not been yet achieved.

Citing Articles

The impact of pathogen sensitivity to antibiotics loaded in cement on the number of revisions and costs in the treatment of periprosthetic knee infection.

Davulcu C, Ozer M, Afacan M, Elibollar C, Kaynak G, Unlu M Eur J Orthop Surg Traumatol. 2024; 35(1):42.

PMID: 39708185 DOI: 10.1007/s00590-024-04166-4.

Challenges in Managing Vancomycin Flushing Syndrome Following Vancomycin-Loaded Bone Cement for Periprosthetic Joint Infection: A Case Report.

Motififard M, Teimouri M, Akbari Aghdam H, Ravanbod H, Shahsavan M Arch Bone Jt Surg. 2024; 12(9):674-678.

PMID: 39498219 PMC: 11531771. DOI: 10.22038/ABJS.2024.79046.3626.

Effect of pH and hydroxyapatite-like layer formation on the antibacterial properties of borophosphate bioactive glass incorporated poly(methyl methacrylate) bone cement.

Hageman K, Blatt R, Kuenne W, Brow R, McIff T Front Bioeng Biotechnol. 2024; 12:1462795.

PMID: 39359257 PMC: 11445002. DOI: 10.3389/fbioe.2024.1462795.

No shortening of the patellar tendon during two-stage total knee arthroplasty revision using articulating spacers.

Meissner N, Halder A, Torney O, Preis A, Sina J, Schrednitzki D Arch Orthop Trauma Surg. 2024; 144(9):4437-4441.

PMID: 39294528 DOI: 10.1007/s00402-024-05545-6.

Antimicrobial Regimens in Cement Spacers for Periprosthetic Joint Infections: A Critical Review.

Naoum S, Koutserimpas C, Pantekidis I, Giovanoulis V, Veizi E, Piagkou M Antibiotics (Basel). 2024; 13(8).

PMID: 39200072 PMC: 11351621. DOI: 10.3390/antibiotics13080772.

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