Biomarkers in Retinoblastoma

Overview

Journal Int J Ophthalmol

Specialty Ophthalmology

Date 2020 Feb 25

PMID 32090044

Citations 9

Authors

Jie Sun

Hui-Yu Xi

Qing Shao

Qing-Huai Liu

Affiliations

Soon will be listed here.

Abstract

Retinoblastoma (RB) is the most common intraocular malignancy of childhood caused by inactivation of the genes. The prognosis of RB is better with an earlier diagnosis. Many diagnostic approaches and appropriate clinical treatments have been developed to improve clinical outcomes. However, limitations exist when utilizing current methods. Recently, many studies have identified identify new RB biomarkers which can be used in diagnosis, as prognostic indicators and may contribute to understanding the pathogenesis of RB and help determine specific treatment strategies. This review focuses on recent advances in the discovery of RB biomarkers and discusses their clinical utility and challenges from areas such as epigenetics, proteomics and radiogenomics.

Citing Articles

MicroRNAs' Significance in Retinoblastoma Diagnosis and Treatment: The Little Heroes.

Zamani Sani M, Mirzaei M, Mota A, Mohammadian J, Beilankouhi E, Rahmati M Biochem Genet. 2025; .

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Trefoil Family Factor Peptide 1-A New Biomarker in Liquid Biopsies of Retinoblastoma under Therapy.

Busch M, Haase A, Alefeld E, Biewald E, Jabbarli L, Dunker N Cancers (Basel). 2023; 15(19).

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Genetics in ophthalmology: molecular blueprints of retinoblastoma.

Markovic L, Bukovac A, Varosanec A, Slaus N, Pecina-Slaus N Hum Genomics. 2023; 17(1):82.

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Zebrafish as an Orthotopic Tumor Model for Retinoblastoma Mimicking Routes of Human Metastasis.

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Genome maintenance in retinoblastoma: Implications for therapeutic vulnerabilities.

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