Genetic Predisposition to Myelodysplastic Syndrome in Clinical Practice

Overview

Journal Hematol Oncol Clin North Am

Specialties Hematology
Oncology

Date 2020 Feb 25

PMID 32089214

Citations 10

Authors

Kristen E Schratz

Amy E DeZern

Affiliations

Soon will be listed here.

Abstract

Myelodysplastic syndromes (MDSs) are a heterogeneous group of marrow failure disorders that primarily affect older persons but also occur at a lower frequency in children and young adults. There is increasing recognition of an inherited predisposition to MDS as well as other myeloid malignancies for patients of all ages. Germline predisposition to MDS can occur as part of a syndrome or sporadic disease. The timely diagnosis of an underlying genetic predisposition in the setting of MDS is important. This article delineates germline genetic causes of MDS and provides a scaffold for the diagnosis and management of patients in this context.

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