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Basophil Activation Test in Cancer Patient Blood Evaluating Potential Hypersensitivity to an Anti-tumor IgE Therapeutic Candidate

Overview
Journal Allergy
Specialty Allergy & Immunology
Date 2020 Feb 23
PMID 32086828
Citations 9
Authors
Heather J Bax
Atousa Khiabany
Chara Stavraka
Giulia Pellizzari
Charleen Chan Wah Hak
Alexandra Robinson
Kristina M Ilieva
Natalie Woodman
Cristina Naceur-Lombardelli
Cheryl Gillett
Sarah Pinder
Hannah J Gould
Christopher J Corrigan
Stephen J Till
Sidath Katugampola
Claire Barton
Anna Winship
Sharmistha Ghosh
Ana Montes
Debra H Josephs
James F Spicer
Sophia N Karagiannis
Affiliations
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Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4.

Chauhan J, Grandits M, Palhares L, Mele S, Nakamura M, Lopez-Abente J Nat Commun. 2023; 14(1):2192.

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Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes.

Bax H, Chauhan J, Stavraka C, Santaolalla A, Osborn G, Khiabany A Br J Cancer. 2022; 128(2):342-353.

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Clinical and Translational Significance of Basophils in Patients with Cancer.

Chauhan J, Stavraka C, Grandits M, Palhares L, Josephs D, Lacy K Cells. 2022; 11(3).

PMID: 35159247 PMC: 8833920. DOI: 10.3390/cells11030438.

trafficking of a tumor-targeting IgE antibody: molecular imaging demonstrates rapid hepatobiliary clearance compared to IgG counterpart.

Man F, Koers A, Karagiannis P, Josephs D, Bax H, Gilbert A Oncoimmunology. 2021; 10(1):1966970.

PMID: 34513315 PMC: 8425638. DOI: 10.1080/2162402X.2021.1966970.

References
1.
Pellizzari G, Hoskin C, Crescioli S, Mele S, Gotovina J, Chiaruttini G . IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states. EBioMedicine. 2019; 43:67-81. PMC: 6562024. DOI: 10.1016/j.ebiom.2019.03.080. View
2.
Josephs D, Bax H, Dodev T, Georgouli M, Nakamura M, Pellizzari G . Anti-Folate Receptor-α IgE but not IgG Recruits Macrophages to Attack Tumors via TNFα/MCP-1 Signaling. Cancer Res. 2017; 77(5):1127-1141. PMC: 6173310. DOI: 10.1158/0008-5472.CAN-16-1829. View
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Josephs D, Nakamura M, Bax H, Dodev T, Muirhead G, Saul L . An immunologically relevant rodent model demonstrates safety of therapy using a tumour-specific IgE. Allergy. 2018; 73(12):2328-2341. PMC: 6492130. DOI: 10.1111/all.13455. View
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Chung C, Mirakhur B, Chan E, Le Q, Berlin J, Morse M . Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose. N Engl J Med. 2008; 358(11):1109-17. PMC: 2361129. DOI: 10.1056/NEJMoa074943. View
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Giavina-Bianchi P, Galvao V, Picard M, Caiado J, Castells M . Basophil Activation Test is a Relevant Biomarker of the Outcome of Rapid Desensitization in Platinum Compounds-Allergy. J Allergy Clin Immunol Pract. 2016; 5(3):728-736. DOI: 10.1016/j.jaip.2016.11.006. View