NH-MIL-53(Al) Polymer Monolithic Column for In-Tube Solid-Phase Microextraction Combined with UHPLC-MS/MS for Detection of Trace Sulfonamides in Food Samples

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Feb 23

PMID 32085411

Citations 1

Authors

Qian-Chun Zhang

Guang-Ping Xia

Jun-Yi Liang

Xiao-Lan Zhang

Li Jiang

Yu-Guo Zheng

Xing-Yi Wang

Affiliations

Soon will be listed here.

Abstract

In this study, a novel monolithic capillary column based on a NH-MIL-53(Al) metal-organic framework (MOF) incorporated in poly (3-acrylamidophenylboronic acid/methacrylic acid-co-ethylene glycol dimethacrylate) (poly (AAPBA/MAA-co-EGDMA)) was prepared using an in situ polymerization method. The characteristics of the MOF-polymer monolithic column were investigated by scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffractometry, Brunauer-Emmett-Teller analysis, and thermogravimetric analysis. The prepared MOF-polymer monolithic column showed good permeability, high extraction efficiency, chemical stability, and good reproducibility. The MOF-polymer monolithic column was used for in-tube solid-phase microextraction (SPME) to efficiently adsorb trace sulfonamides from food samples. A novel method combining MOF-polymer-monolithic-column-based SPME with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was successfully developed. The linear range was from 0.015 to 25.0 µg/L, with low limits of detection of 1.3-4.7 ng/L and relative standard deviations (RSDs) of < 6.1%. Eight trace sulfonamides in fish and chicken samples were determined, with recoveries of the eight analytes ranging from 85.7% to 113% and acceptable RSDs of < 7.3%. These results demonstrate that the novel MOF-polymer-monolithic-column-based SPME coupled with UHPLC-MS/MS is a highly sensitive, practical, and convenient method for monitoring trace sulfonamides in food samples previously extracted with an adequate solvent.

Citing Articles

Development of polymer monolith-MOF hybrid via surface functionalization for bioanalytical sciences.

Ali K, Munawar I, Manan S, Nawazish F, Fatima B, Jabeen F Anal Bioanal Chem. 2025; .

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Functionalized monolithic columns: Recent advancements and their applications for high-efficiency separation and enrichment in food and medicine.

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