Rational Design of Block Copolymer Self-assemblies in Photodynamic Therapy

Overview

Journal Beilstein J Nanotechnol

Specialty Biotechnology

Date 2020 Feb 22

PMID 32082960

Citations 7

Authors

Maxime Demazeau

Laure Gibot

Anne-Francoise Mingotaud

Patricia Vicendo

Clement Roux

Barbara Lonetti

Affiliations

Soon will be listed here.

Abstract

Photodynamic therapy is a technique already used in ophthalmology or oncology. It is based on the local production of reactive oxygen species through an energy transfer from an excited photosensitizer to oxygen present in the biological tissue. This review first presents an update, mainly covering the last five years, regarding the block copolymers used as nanovectors for the delivery of the photosensitizer. In particular, we describe the chemical nature and structure of the block copolymers showing a very large range of existing systems, spanning from natural polymers such as proteins or polysaccharides to synthetic ones such as polyesters or polyacrylates. A second part focuses on important parameters for their design and the improvement of their efficiency. Finally, particular attention has been paid to the question of nanocarrier internalization and interaction with membranes (both biomimetic and cellular), and the importance of intracellular targeting has been addressed.

Citing Articles

Intracellular Fate of the Photosensitizer Chlorin e4 with Different Carriers and Induced Metabolic Changes Studied by H NMR Spectroscopy.

Vermathen M, Kampfer T, Nuoffer J, Vermathen P Pharmaceutics. 2023; 15(9).

PMID: 37765292 PMC: 10537485. DOI: 10.3390/pharmaceutics15092324.

Terahertz Spectroscopy Sheds Light on Real-Time Exchange Kinetics Occurring through Plasma Membrane during Photodynamic Therapy Treatment.

Zheng X, Lordon B, Mingotaud A, Vicendo P, Brival R, Fourquaux I Adv Sci (Weinh). 2023; 10(18):e2300589.

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Applications of Photodynamic Therapy in Endometrial Diseases.

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Vertical Cylinder-to-Lamella Transition in Thin Block Copolymer Films Induced by In-Plane Electric Field.

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