Excretion of Tiapamil in Breast Milk

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1988 Aug 1

PMID 3207555

Citations 1

Authors

D Hartmann

N O LUNELL

G Friedrich

A Rane

Affiliations

Soon will be listed here.

Abstract

The excretion of tiapamil in breast milk was studied in six lactating mothers (3-7 days post partum) following a single oral 600 mg dose of the drug. The milk/plasma ratio of tiapamil derived from the areas under the plasma and milk concentration-time curves was 0.44 +/- 0.10 mean +/- s.d.). Assuming an intake of 350 ml of milk during a dosing interval of 12 h, the newborn would be exposed at the maximum to 0.053 mg tiapamil. This small amount does not represent a risk for the baby.

Citing Articles

Prospective evaluation of a model for the prediction of milk:plasma drug concentrations from physicochemical characteristics.

Begg E, Atkinson H, Duffull S Br J Clin Pharmacol. 1992; 33(5):501-5.

PMID: 1524962 PMC: 1381436. DOI: 10.1111/j.1365-2125.1992.tb04077.x.

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