Preoperative Treatment of Thyrotoxicosis in Developing Countries: a Comparative Study of Carbimazole and Propranolol

Overview

Journal Ann R Coll Surg Engl

Specialty General Surgery

Date 1988 Nov 1

PMID 3207325

Authors

J F Haddad

S Tibblin

Affiliations

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Abstract

Preoperative management of treatment in thyrotoxicosis was investigated in a comparative study of carbimazole and propranolol in 41 consecutive patients collected during a 3-year period. The groups included 20 and 21 patients respectively, of equal sex and age distribution and of similar severity. The length of the preoperative treatment was significantly reduced in the propranolol pretreated patients (P greater than 0.001). Intraoperative blood loss, postoperative function with regard to the thyroid, parathyroids and vocal cords were similar in both groups. Three and two patients respectively had permanent hypothyroidism requiring thyroxin treatment. In patients with therapy compliance problems treatment with propranolol would entail a definite advantage, particularly in developing countries.

References

Vinik A, Pimstone B, Hoffenberg R . Sympathetic nervous system blocking in hyperthyroidism. J Clin Endocrinol Metab. 1968; 28(5):725-7. DOI: 10.1210/jcem-28-5-725. View

SHAND D, Nuckolls E, OATES J . Plasma propranolol levels in adults with observations in four children. Clin Pharmacol Ther. 1970; 11(1):112-20. DOI: 10.1002/cpt1970111112. View

MICHIE W, Duncan T, Hamer-Hodges D, BEWSHER P, STOWERS J, Pegg C . Mechanism of hypocalcaemia after thyroidectomy for thyrotoxicosis. Lancet. 1971; 1(7698):508-14. DOI: 10.1016/s0140-6736(71)91122-6. View

Lee T, Coffey R, MACKIN J, Cobb M, Routon J, CANARY J . The use of propranolol in the surgical treatment of thyrotoxic patients. Ann Surg. 1973; 177(6):643-7. PMC: 1355934. View

MICHIE W, Pegg C, ORR F, BEWSHER P . Beta-blockade and partial thyroidectomy for thyrotoxicosis. Lancet. 1974; 1(7865):1009-11. DOI: 10.1016/s0140-6736(74)90414-0. View

Ljunggren J, Persson B . Preoperative treatment of thyrotoxicosis with a beta-adrenergic blocking agent. Acta Chir Scand. 1975; 141(8):715-8. View

Toft A, Irvine W, McIntosh D, MacLeod D, Seth J, Cameron E . Propranolol in the treatment of thyrotoxicosis by subtotal thyroidectomy. J Clin Endocrinol Metab. 1976; 43(6):1312-6. DOI: 10.1210/jcem-43-6-1312. View

Eriksson M, RUBENFELD S, Garber A, Kohler P . Propranolol does not prevent thyroid storm. N Engl J Med. 1977; 296(5):263-4. DOI: 10.1056/NEJM197702032960509. View

Wilkin T, ISLES T, Paterson C, Crooks J, Beck J . Post-thyroidectomy hypocalcaemia: A feature of the operation or the thyroid disorder?. Lancet. 1977; 1(8012):621-3. DOI: 10.1016/s0140-6736(77)92057-8. View

10.

Levy C, Waite J, Dickey R . Thyrotoxicosis and pregnancy. Use of preoperative propranolol for thyroidectomy. Am J Surg. 1977; 133(3):319-21. DOI: 10.1016/0002-9610(77)90537-2. View

11.

Toft A, Irvine W, Sinclair I, McIntosh D, Seth J, Cameron E . Thyroid function after surgical treatment of thyrotoxicosis. A report of 100 cases treated with propranolol before operation. N Engl J Med. 1978; 298(12):643-7. DOI: 10.1056/NEJM197803232981202. View

12.

CASWELL H, Marks A, CHANNICK B . Propranolol for the preoperative preparation of patients with thyrotoxicosis. Surg Gynecol Obstet. 1978; 146(6):908-10. View

13.

Kapur M, Sarin R, Kumar V, Ananthakrishnan N, Joshi K . Evaluation of propranolol in the preoperative control of thyrotoxicosis. Indian J Med Res. 1978; 67:453-61. View

14.

Tevaarwerk G, Boyd D . Propranolol in thyrotoxicosis: II. Serum thyroid hormone concentrations during subtotal thyroidectomy. Can J Surg. 1979; 22(3):264-6. View

15.

Anderberg B, Kagedal B, Nilsson O, Smeds S, Tegler L, Gillquist J . Propranolol and thyroid resection for thyperthyroidism. Acta Chir Scand. 1979; 145(5):297-303. View

16.

Feely J, Forrest A, Gunn A, Hamilton W, Stevenson I, Crooks J . Propranolol dosage in thyrotoxicosis. J Clin Endocrinol Metab. 1980; 51(3):658-61. DOI: 10.1210/jcem-51-3-658. View

17.

Noguchi S, Murakami N, Noguchi A . Surgical treatment for Graves' disease: a long term follow-up of 325 patients. Br J Surg. 1981; 68(2):105-8. DOI: 10.1002/bjs.1800680213. View

18.

Feely J, Crooks J, Forrest A, HAMILTON W, Gunn A . Propranolol in the surgical treatment of hyperthyroidism, including severely thyrotoxic patients. Br J Surg. 1981; 68(12):865-9. DOI: 10.1002/bjs.1800681211. View

19.

Sugrue D, Drury M, McEvoy M, Heffernan S, OMalley E . Long term follow-up of hyperthyroid patients treated by subtotal thyroidectomy. Br J Surg. 1983; 70(7):408-11. DOI: 10.1002/bjs.1800700706. View

20.

Lee K, Kim K, HUR K, Kim C . The role of propranolol in the preoperative preparation of patients with Graves' disease. Surg Gynecol Obstet. 1986; 162(4):365-9. View