Novel Basic Science Insights to Improve the Management of Heart Failure: Review of the Working Group on Cellular and Molecular Biology of the Heart of the Italian Society of Cardiology

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Feb 15

PMID 32054029

Citations 5

Authors

Pietro Ameri

Gabriele Giacomo Schiattarella

Lia Crotti

Margherita Torchio

Edoardo Bertero

Daniele Rodolico

Maurizio Forte

Vittoria Di Mauro

Roberta Paolillo

Cristina Chimenti

Daniele Torella

Daniele Catalucci

Sebastiano Sciarretta

Cristina Basso

Ciro Indolfi

Cinzia Perrino

Affiliations

Soon will be listed here.

Abstract

Despite important advances in diagnosis and treatment, heart failure (HF) remains a syndrome with substantial morbidity and dismal prognosis. Although implementation and optimization of existing technologies and drugs may lead to better management of HF, new or alternative strategies are desirable. In this regard, basic science is expected to give fundamental inputs, by expanding the knowledge of the pathways underlying HF development and progression, identifying approaches that may improve HF detection and prognostic stratification, and finding novel treatments. Here, we discuss recent basic science insights that encompass major areas of translational research in HF and have high potential clinical impact.

Citing Articles

The treatment with trandolapril and losartan attenuates pressure and volume overload alternations of cardiac connexin-43 and extracellular matrix in Ren-2 transgenic rats.

Sykora M, Kratky V, Cervenka L, Kopkan L, Tribulova N, Szeiffova Bacova B Sci Rep. 2023; 13(1):20923.

PMID: 38017033 PMC: 10684879. DOI: 10.1038/s41598-023-48259-2.

Forkhead box O6 (FoxO6) promotes cardiac pathological remodeling and dysfunction by activating Kif15-TGF-β1 under aggravated afterload.

Zhang B, Shi L, Tan Y, Zhou Y, Cui J, Song Y MedComm (2020). 2023; 4(5):e383.

PMID: 37799807 PMC: 10547936. DOI: 10.1002/mco2.383.

From Genetic Mutations to Molecular Basis of Heart Failure Treatment: An Overview of the Mechanism and Implication of the Novel Modulators for Cardiac Myosin.

Chen Y, Chien C, Chiang C, Chen C, Cheng H Int J Mol Sci. 2021; 22(12).

PMID: 34205587 PMC: 8234187. DOI: 10.3390/ijms22126617.

The Neuroimmune Role of Intestinal Microbiota in the Pathogenesis of Cardiovascular Disease.

Suslov A, Chairkina E, Shepetovskaya M, Suslova I, Khotina V, Kirichenko T J Clin Med. 2021; 10(9).

PMID: 34066528 PMC: 8124579. DOI: 10.3390/jcm10091995.

Exploring the Potential Role of the Gut Microbiome in Chemotherapy-Induced Neurocognitive Disorders and Cardiovascular Toxicity.

Ciernikova S, Mego M, Chovanec M Cancers (Basel). 2021; 13(4).

PMID: 33668518 PMC: 7918783. DOI: 10.3390/cancers13040782.

References

Haghighi K, Kolokathis F, Gramolini A, Waggoner J, Pater L, Lynch R . A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proc Natl Acad Sci U S A. 2006; 103(5):1388-93. PMC: 1360586. DOI: 10.1073/pnas.0510519103. View

Choi A, Ryter S, Levine B . Autophagy in human health and disease. N Engl J Med. 2013; 368(19):1845-6. DOI: 10.1056/NEJMc1303158. View

Pantos C, Mourouzis I, Saranteas T, Clave G, Ligeret H, Noack-Fraissignes P . Thyroid hormone improves postischaemic recovery of function while limiting apoptosis: a new therapeutic approach to support hemodynamics in the setting of ischaemia-reperfusion?. Basic Res Cardiol. 2008; 104(1):69-77. DOI: 10.1007/s00395-008-0758-4. View

Teekakirikul P, Kelly M, Rehm H, Lakdawala N, Funke B . Inherited cardiomyopathies: molecular genetics and clinical genetic testing in the postgenomic era. J Mol Diagn. 2013; 15(2):158-70. DOI: 10.1016/j.jmoldx.2012.09.002. View

Priori S, Blomstrom-Lundqvist C . 2015 European Society of Cardiology Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death summarized by co-chairs. Eur Heart J. 2016; 36(41):2757-9. DOI: 10.1093/eurheartj/ehv445. View

Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M . The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med. 2007; 13(5):619-24. DOI: 10.1038/nm1574. View

Rizvi S, Saleh A . Applications of nanoparticle systems in drug delivery technology. Saudi Pharm J. 2018; 26(1):64-70. PMC: 5783816. DOI: 10.1016/j.jsps.2017.10.012. View

Chambers E, Preston T, Frost G, Morrison D . Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health. Curr Nutr Rep. 2018; 7(4):198-206. PMC: 6244749. DOI: 10.1007/s13668-018-0248-8. View

Sciarretta S, Maejima Y, Zablocki D, Sadoshima J . The Role of Autophagy in the Heart. Annu Rev Physiol. 2017; 80:1-26. DOI: 10.1146/annurev-physiol-021317-121427. View

10.

Branchereau M, Burcelin R, Heymes C . The gut microbiome and heart failure: A better gut for a better heart. Rev Endocr Metab Disord. 2019; 20(4):407-414. DOI: 10.1007/s11154-019-09519-7. View

11.

Tang W, Li D, Hazen S . Dietary metabolism, the gut microbiome, and heart failure. Nat Rev Cardiol. 2018; 16(3):137-154. PMC: 6377322. DOI: 10.1038/s41569-018-0108-7. View

12.

Takagi H, Matsui Y, Sadoshima J . The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart. Antioxid Redox Signal. 2007; 9(9):1373-81. DOI: 10.1089/ars.2007.1689. View

13.

Li S, Ji Z, Zou M, Nie X, Shi Y, Cheng G . Preparation, characterization, pharmacokinetics and tissue distribution of solid lipid nanoparticles loaded with tetrandrine. AAPS PharmSciTech. 2011; 12(3):1011-8. PMC: 3167269. DOI: 10.1208/s12249-011-9665-3. View

14.

Cao D, Schiattarella G, Villalobos E, Jiang N, May H, Li T . Cytosolic DNA Sensing Promotes Macrophage Transformation and Governs Myocardial Ischemic Injury. Circulation. 2018; 137(24):2613-2634. PMC: 5997506. DOI: 10.1161/CIRCULATIONAHA.117.031046. View

15.

De Bortoli M, Postma A, Poloni G, Calore M, Minervini G, Mazzotti E . Whole-Exome Sequencing Identifies Pathogenic Variants in TJP1 Gene Associated With Arrhythmogenic Cardiomyopathy. Circ Genom Precis Med. 2018; 11(10):e002123. DOI: 10.1161/CIRCGEN.118.002123. View

16.

Prokop A, Davidson J . Nanovehicular intracellular delivery systems. J Pharm Sci. 2008; 97(9):3518-90. PMC: 3747665. DOI: 10.1002/jps.21270. View

17.

Kiffin R, Christian C, Knecht E, Cuervo A . Activation of chaperone-mediated autophagy during oxidative stress. Mol Biol Cell. 2004; 15(11):4829-40. PMC: 524731. DOI: 10.1091/mbc.e04-06-0477. View

18.

Schiattarella G, Sannino A, Esposito G, Perrino C . Diagnostics and therapeutic implications of gut microbiota alterations in cardiometabolic diseases. Trends Cardiovasc Med. 2018; 29(3):141-147. DOI: 10.1016/j.tcm.2018.08.003. View

19.

Lam C, Voors A, de Boer R, Solomon S, Van Veldhuisen D . Heart failure with preserved ejection fraction: from mechanisms to therapies. Eur Heart J. 2018; 39(30):2780-2792. DOI: 10.1093/eurheartj/ehy301. View

20.

Bartlett J, Trivedi P, Yeung P, Kienesberger P, Pulinilkunnil T . Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy. Biochem J. 2016; 473(21):3769-3789. DOI: 10.1042/BCJ20160385. View