Hydrogen Sulfide As Potential Regulatory in Arthritic Diseases

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Feb 15

PMID 32053981

Citations 29

Authors

Flavia Sunzini

Susanna De Stefano

Maria Sole Chimenti

Sonia Melino

Affiliations

Soon will be listed here.

Abstract

The social and economic impact of chronic inflammatory diseases, such as arthritis, explains the growing interest of the research in this field. The antioxidant and anti-inflammatory properties of the endogenous hydrogen sulfide (HS) were recently demonstrated in the context of different inflammatory diseases. In particular, HS is able to suppress the production of pro-inflammatory mediations by lymphocytes and innate immunity cells. Considering these biological effects of HS, a potential role in the treatment of inflammatory arthritis, such as rheumatoid arthritis (RA), can be postulated. However, despite the growing interest in HS, more evidence is needed to understand the pathophysiology and the potential of HS as a therapeutic agent. Within this review, we provide an overview on HS biological effects, on its role in immune-mediated inflammatory diseases, on HS releasing drugs, and on systems of tissue repair and regeneration that are currently under investigation for potential therapeutic applications in arthritic diseases.

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References

Nettles D, Vail T, Morgan M, Grinstaff M, Setton L . Photocrosslinkable hyaluronan as a scaffold for articular cartilage repair. Ann Biomed Eng. 2004; 32(3):391-7. DOI: 10.1023/b:abme.0000017552.65260.94. View

Searcy D, Lee S . Sulfur reduction by human erythrocytes. J Exp Zool. 1998; 282(3):310-22. DOI: 10.1002/(sici)1097-010x(19981015)282:3<310::aid-jez4>3.0.co;2-p. View

Andruski B, McCafferty D, Ignacy T, Millen B, McDougall J . Leukocyte trafficking and pain behavioral responses to a hydrogen sulfide donor in acute monoarthritis. Am J Physiol Regul Integr Comp Physiol. 2008; 295(3):R814-20. DOI: 10.1152/ajpregu.90524.2008. View

Huang C, Feng W, Peh M, Peh K, Dymock B, Moore P . A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo. Pharmacol Res. 2016; 113(Pt A):533-546. DOI: 10.1016/j.phrs.2016.09.032. View

Zhang Q, Liu S, Li T, Yuan L, Liu H, Wang X . Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential. Oncotarget. 2016; 7(36):58089-58104. PMC: 5295414. DOI: 10.18632/oncotarget.11166. View

Liang W, Chen J, Li L, Li M, Wei X, Tan B . Conductive Hydrogen Sulfide-Releasing Hydrogel Encapsulating ADSCs for Myocardial Infarction Treatment. ACS Appl Mater Interfaces. 2019; 11(16):14619-14629. DOI: 10.1021/acsami.9b01886. View

Sen N, Paul B, Gadalla M, Mustafa A, Sen T, Xu R . Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. Mol Cell. 2012; 45(1):13-24. PMC: 3261430. DOI: 10.1016/j.molcel.2011.10.021. View

Coletta C, Papapetropoulos A, Erdelyi K, Olah G, Modis K, Panopoulos P . Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proc Natl Acad Sci U S A. 2012; 109(23):9161-6. PMC: 3384190. DOI: 10.1073/pnas.1202916109. View

Wells A, Edwards C, Kivitz A, Bird P, Nguyen D, Paris M . Apremilast monotherapy in DMARD-naive psoriatic arthritis patients: results of the randomized, placebo-controlled PALACE 4 trial. Rheumatology (Oxford). 2018; 57(7):1253-1263. PMC: 6014136. DOI: 10.1093/rheumatology/key032. View

10.

Colucci S, Brunetti G, Cantatore F, Oranger A, Mori G, Quarta L . Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis. J Pathol. 2007; 212(1):47-55. DOI: 10.1002/path.2153. View

11.

de Beus M, Chung J, Colon W . Modification of cysteine 111 in Cu/Zn superoxide dismutase results in altered spectroscopic and biophysical properties. Protein Sci. 2004; 13(5):1347-55. PMC: 2286766. DOI: 10.1110/ps.03576904. View

12.

Feng S, Zhao Y, Xian M, Wang Q . Biological thiols-triggered hydrogen sulfide releasing microfibers for tissue engineering applications. Acta Biomater. 2015; 27:205-213. PMC: 4609630. DOI: 10.1016/j.actbio.2015.09.010. View

13.

Tamizhselvi R, Koh Y, Sun J, Zhang H, Bhatia M . Hydrogen sulfide induces ICAM-1 expression and neutrophil adhesion to caerulein-treated pancreatic acinar cells through NF-kappaB and Src-family kinases pathway. Exp Cell Res. 2010; 316(9):1625-36. DOI: 10.1016/j.yexcr.2010.02.044. View

14.

Camer D, Huang X . The endothelin pathway: a protective or detrimental target of bardoxolone methyl on cardiac function in patients with advanced chronic kidney disease?. Am J Nephrol. 2014; 40(3):288-90. DOI: 10.1159/000368563. View

15.

Houslay M, Sullivan M, Bolger G . The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions. Adv Pharmacol. 1998; 44:225-342. DOI: 10.1016/s1054-3589(08)60128-3. View

16.

Wallace J, Ferraz J, Muscara M . Hydrogen sulfide: an endogenous mediator of resolution of inflammation and injury. Antioxid Redox Signal. 2011; 17(1):58-67. PMC: 3342563. DOI: 10.1089/ars.2011.4351. View

17.

Kurien B, Scofield R . Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev. 2008; 7(7):567-73. PMC: 2585037. DOI: 10.1016/j.autrev.2008.04.019. View

18.

Wallace J, Ianaro A, Flannigan K, Cirino G . Gaseous mediators in resolution of inflammation. Semin Immunol. 2015; 27(3):227-33. DOI: 10.1016/j.smim.2015.05.004. View

19.

Wang Q, Liu H, Mu Q, Rose P, Zhu Y . S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway. J Cardiovasc Pharmacol. 2009; 54(2):139-46. DOI: 10.1097/FJC.0b013e3181ac8e12. View

20.

Ekundi-Valentim E, Mesquita F, Santos K, de Paula M, Florenzano J, Zanoni C . A comparative study on the anti-inflammatory effects of single oral doses of naproxen and its hydrogen sulfide (H2S)-releasing derivative ATB-346 in rats with carrageenan-induced synovitis. Med Gas Res. 2013; 3(1):24. PMC: 3843537. DOI: 10.1186/2045-9912-3-24. View