Epidemiological Features and Clinical Presentations of Acute Coronary Syndrome in Young Patients

Overview

Journal Intern Med

Specialty General Medicine

Date 2020 Feb 14

PMID 32051385

Citations 2

Authors

Hiroaki Sawada

Hirohiko Ando

Hiroaki Takashima

Katsuhisa Waseda

Masahiro Shimoda

Hirofumi Ohashi

Akihiro Suzuki

Shinichiro Sakurai

Yusuke Nakano

Tetsuya Amano

Affiliations

Soon will be listed here.

Abstract

Objective Although acute coronary syndrome (ACS) is an uncommon entity in young patients, it constitutes an important problem due to the devastating effects of the disease on the more active lifestyle of young patients. At present, there are no guidelines regarding the prevention of ACS in young patients. Methods We performed a retrospective study of ACS patients between 2014 and 2017. Epidemiological data, clinical findings, and short-term outcomes were evaluated between young ACS patients (≤50 years old) and elderly ACS patients (>50 years old). Results Of a total of 361 consecutive ACS patients, 37 were young ACS patients (10.2%). Compared with elderly ACS patients, young ACS patients showed a higher prevalence of males (94.6% vs. 73.8%, p<0.001), current smoking (70.3% vs. 29.9%; p<0.001), and overweight persons (67.6% vs. 27.8%, p<0.001). The eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio was significantly lower in young ACS patients than in elderly ACS patients [0.17 (0.12-0.25) vs. 0.25 (0.18-0.37), p=0.002]. The prevalence of cardio-pulmonary arrest and percutaneous cardiopulmonary support use was higher in young ACS patients than in elderly ACS patients (24.3% vs. 8.6%, p=0.003, 16.2% vs. 3.1%, p<0.001). Conclusion The features were markedly different between young ACS patients and elderly ACS patients. In young ACS patients, smoking, being overweight, and a low EPA/AA ratio were distinctive risk factors, and more serious clinical presentations were observed at the onset of ACS than in older patients.

Citing Articles

Clinical Presentation and In-Hospital Outcomes of Acute Myocardial Infarction in Young Patients: Japanese Nationwide Registry.

Ando H, Yamaji K, Kohsaka S, Ishii H, Sakakura K, Goto R JACC Asia. 2022; 2(5):574-585.

PMID: 36518720 PMC: 9743453. DOI: 10.1016/j.jacasi.2022.03.013.

Increased Risk of Acute Coronary Syndrome in Ankylosing Spondylitis Patients With Uveitis: A Population-Based Cohort Study.

Feng K, Chien W, Chen Y, Sun C, Chung C, Chen J Front Immunol. 2022; 13:890543.

PMID: 35757729 PMC: 9226308. DOI: 10.3389/fimmu.2022.890543.

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