Niacin-ligated Platinum(iv)-ruthenium(ii) Chimeric Complexes Synergistically Suppress Tumor Metastasis and Growth with Potentially Reduced Toxicity in Vivo

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2020 Feb 13

PMID 32049075

Citations 4

Authors

Liwei Shu

Lulu Ren

Yuchen Wang

Tao Fang

Zhijian Ye

Weidong Han

Chao Chen

Hangxiang Wang

Affiliations

Soon will be listed here.

Abstract

Niacin-ligated platinum(iv)-ruthenium(ii) chimeric complexes (PtRu 1-4) have been synthesized and evaluated for their antitumor performance. Using the optimal complex, PtRu-1, we show that this water-soluble chimeric prodrug not only potently inhibits the metastasis and proliferation of tumor cells but also has an unexpectedly higher safety margin in animals compared with the traditionally-used, clinically approved drug cisplatin.

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