Calcium Transport Proteins in Fungi: The Phylogenetic Diversity of Their Relevance for Growth, Virulence, and Stress Resistance

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2020 Feb 13

PMID 32047484

Citations 24

Authors

Mario Lange

Edgar Peiter

Affiliations

Soon will be listed here.

Abstract

The key players of calcium (Ca) homeostasis and Ca signal generation, which are Ca channels, Ca/H antiporters, and Ca-ATPases, are present in all fungi. Their coordinated action maintains a low Ca baseline, allows a fast increase in free Ca concentration upon a stimulus, and terminates this Ca elevation by an exponential decrease - hence forming a Ca signal. In this respect, the Ca signaling machinery is conserved in different fungi. However, does the similarity of the genetic inventory that shapes the Ca peak imply that if "you've seen one, you've seen them all" in terms of physiological relevance? Individual studies have focused mostly on a single species, and mechanisms elucidated in few model organisms are usually extrapolated to other species. This mini-review focuses on the physiological relevance of the machinery that maintains Ca homeostasis for growth, virulence, and stress responses. It reveals common and divergent functions of homologous proteins in different fungal species. In conclusion, for the physiological role of these Ca transport proteins, "seen one," in many cases, does not mean: "seen them all."

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