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Plasma Rich in Growth Factor Gel As an Autologous Filler for Facial Volume Restoration

Overview
Specialty Dermatology
Date 2020 Feb 12
PMID 32045103
Citations 7
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Abstract

Background: Skin aging is characterized by moderate to severe wrinkles, laxity, roughness, and volume loss as a result of cutaneous atrophy and connective tissue degradation. Plasma rich in growth factor gel (PRGF-gel) is a novel formulation obtained from the patient's own blood that has demonstrated optimal biomechanical and bioactive properties for soft tissue restoration.

Objectives: Following a retrospective design, the clinical safety and efficacy of PRGF-gel for facial volume restoration and skin rejuvenation were evaluated.

Methods: Twenty women clinically diagnosed for aged skin symptoms were treated with PRGF-gel. Participants received an individualized regimen depending on their therapeutic needs. At the end of the follow-up periods, clinical performance analysis was evaluated by standardized macrophotographs along with clinical and patient surveys based on Likert's scales.

Results: Based on their initial expectations, patients referred to be highly satisfied after PRGF-gel treatment in terms of fine line amelioration, wrinkle reduction, and sagging improvement (overall satisfaction of 8/10). Pre/post-photograph clinical evaluation showed an improvement of 2.5/3 and patients presented a noticeable face rejuvenation due to the soft tissue augmentation effect which was translated into surface texture softening and tone recovery.

Conclusions: Although additional randomized clinical trials should be carried out, this study provides preliminary data supporting the use of PRGF-gel for facial volume restoration.

Citing Articles

In Vivo Assessment of Plasma Gel: Regenerative Potential and Limitations as a Filler.

Cheng H, Li J, Zhao Y, Xia X, Li Y J Cosmet Dermatol. 2025; 24(2):e16765.

PMID: 39918180 PMC: 11804155. DOI: 10.1111/jocd.16765.


Combined Therapy with Laser and Autologous Topical Serum for Facial Rejuvenation: A Multiple Case Series Report.

Navarro R, Pino A, Martinez A, Garrigos E, Grau M, Gallego E J Cutan Aesthet Surg. 2023; 15(4):363-370.

PMID: 37035594 PMC: 10081471. DOI: 10.4103/JCAS.JCAS_159_21.


Therapeutic Efficacy of a Plasma Rich in Growth Factors Gel Combined with Fractional Ablative Laser in the Management of Post-acne Scars.

Alegre A, Pino A, Jimenez N, Jaen P, Anitua E J Cutan Aesthet Surg. 2023; 15(4):405-411.

PMID: 37035588 PMC: 10081464. DOI: 10.4103/JCAS.JCAS_160_21.


Efficacy of Platelet-Rich Plasma in Women with a History of Embryo Transfer Failure: A Systematic Review and Meta-Analysis with Trial Sequential Analysis.

Anitua E, Allende M, Fuente M, Fabbro M, Alkhraisat M Bioengineering (Basel). 2023; 10(3).

PMID: 36978694 PMC: 10045363. DOI: 10.3390/bioengineering10030303.


Effectiveness of Hyaluronic Acid Gel Injection with and without PRGF for Management of Interdental Papillary Loss: A Randomized Clinical Trial.

Bal A, Panda S, Mohanty R, Satpathy A, Nayak R, Tumedei M J Funct Biomater. 2023; 14(2).

PMID: 36826913 PMC: 9967875. DOI: 10.3390/jfb14020114.