Association Between BAK1 Gene Rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2020 Feb 11

PMID 32038496

Citations 1

Authors

Jiaxuan Qin

Yufeng Yang

Xuan Zhuang

Jinchun Xing

Affiliations

Soon will be listed here.

Abstract

Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis. Studies associated with BAK1 rs210138 and TGCT was systematically searched in databases. The effect size was pooled according to ORs and 95% CIs. Our systematic review and meta-analysis comprised 14 articles. Significantly increased risk of TGCT was found in eligible GWAS and follow-up studies, in overall group and its Caucasian subgroup. Compared with adenine (A), BAK1 rs210138 guanine (G) is associated with increased risk of TGCT. Well-planned studies with larger sample size and more subgroups are needed to verify the risk identified in our systematic review and meta-analysis.

Citing Articles

Gastric adenocarcinoma with germ cell tumor components: a rare case report.

Han X, Wang S, He H, Sun Y, Li J J Int Med Res. 2022; 50(1):3000605211069202.

PMID: 34986675 PMC: 8743960. DOI: 10.1177/03000605211069202.

References

Lessel D, Gamulin M, Kulis T, Toliat M, Grgic M, Friedrich K . Replication of genetic susceptibility loci for testicular germ cell cancer in the Croatian population. Carcinogenesis. 2012; 33(8):1548-52. DOI: 10.1093/carcin/bgs218. View

Litchfield K, Levy M, Orlando G, Loveday C, Law P, Migliorini G . Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor. Nat Genet. 2017; 49(7):1133-1140. PMC: 6016736. DOI: 10.1038/ng.3896. View

Schumacher F, Wang Z, Skotheim R, Koster R, Chung C, Hildebrandt M . Testicular germ cell tumor susceptibility associated with the UCK2 locus on chromosome 1q23. Hum Mol Genet. 2013; 22(13):2748-53. PMC: 3674801. DOI: 10.1093/hmg/ddt109. View

Katz S, Fisher J, Correll M, Bronson R, Ligon K, Walensky L . Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene. 2012; 32(35):4078-85. PMC: 3529761. DOI: 10.1038/onc.2012.421. View

Rapley E, Turnbull C, Olama A, Dermitzakis E, Linger R, Huddart R . A genome-wide association study of testicular germ cell tumor. Nat Genet. 2009; 41(7):807-10. PMC: 2871592. DOI: 10.1038/ng.394. View

Litchfield K, Shipley J, Turnbull C . Common variants identified in genome-wide association studies of testicular germ cell tumour: an update, biological insights and clinical application. Andrology. 2015; 3(1):34-46. DOI: 10.1111/andr.304. View

Kratz C, Han S, Rosenberg P, Berndt S, Burdett L, Yeager M . Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour. J Med Genet. 2011; 48(7):473-6. PMC: 3131696. DOI: 10.1136/jmedgenet-2011-100001. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009; 62(10):1006-12. DOI: 10.1016/j.jclinepi.2009.06.005. View

Chung C, Kanetsky P, Wang Z, Hildebrandt M, Koster R, Skotheim R . Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet. 2013; 45(6):680-5. PMC: 3723930. DOI: 10.1038/ng.2634. View

10.

Poynter J, Hooten A, Frazier A, Ross J . Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors. Genes Chromosomes Cancer. 2011; 51(3):266-71. DOI: 10.1002/gcc.20951. View

11.

Wang Z, McGlynn K, Rajpert-De Meyts E, Bishop D, Chung C, Dalgaard M . Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. Nat Genet. 2017; 49(7):1141-1147. PMC: 5490654. DOI: 10.1038/ng.3879. View

12.

Qin J, Xing J, Liu R, Chen B, Chen Y, Zhuang X . Association between CD40 rs1883832 and immune-related diseases susceptibility: A meta-analysis. Oncotarget. 2017; 8(60):102235-102243. PMC: 5731949. DOI: 10.18632/oncotarget.18704. View

13.

Dantsev I, Ivkin E, Tryakin A, Godlevski D, Latyshev O, Rudenko V . Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis. Asian J Androl. 2018; 20(6):593-599. PMC: 6219295. DOI: 10.4103/aja.aja_54_18. View

14.

Marcotte E, Pankratz N, Amatruda J, Frazier A, Krailo M, Davies S . Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group. Genes Chromosomes Cancer. 2017; 56(7):548-558. PMC: 5612339. DOI: 10.1002/gcc.22457. View

15.

Ruark E, Seal S, McDonald H, Zhang F, Elliot A, Lau K . Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. Nat Genet. 2013; 45(6):686-9. PMC: 3680037. DOI: 10.1038/ng.2635. View

16.

Kristiansen W, Karlsson R, Rounge T, Whitington T, Andreassen B, Magnusson P . Two new loci and gene sets related to sex determination and cancer progression are associated with susceptibility to testicular germ cell tumor. Hum Mol Genet. 2015; 24(14):4138-46. DOI: 10.1093/hmg/ddv129. View

17.

Kanetsky P, Mitra N, Vardhanabhuti S, Vaughn D, Li M, Ciosek S . A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility. Hum Mol Genet. 2011; 20(15):3109-17. PMC: 3131044. DOI: 10.1093/hmg/ddr207. View