The Relationship of Blood Lead to Systolic Blood Pressure in a Longitudinal Study of Policemen

Overview

Journal Environ Health Perspect

Date 1988 Jun 1

PMID 3203646

Citations 4

Authors

S T Weiss

A Munoz

A Stein

D Sparrow

F E Speizer

Affiliations

Soon will be listed here.

Abstract

We examined the relationship of blood lead level to systolic and diastolic blood pressure in a longitudinal study of 89 Boston, MA, policemen. At the second examination blood lead level and blood pressure were measured in triplicate. Blood pressure measurements were taken in a similar fashion in years 3, 4, and 5. Multivariate analysis using a first-order autoregressive model revealed that after adjusting for previous systolic blood pressure, body mass index, age, and cigarette smoking, an elevated blood lead level was a significant predictor of subsequent systolic blood pressure. Bootstrap simulations of these models provided supporting evidence for the observed association. These data suggest that blood lead level can influence systolic blood pressure even within the normal range.

Citing Articles

Association between blood lead and blood pressure: a population-based study in Brazilian adults.

de Almeida Lopes A, Silbergeld E, Navas-Acien A, Zamoiski R, da Cunha Martins Jr A, Camargo A Environ Health. 2017; 16(1):27.

PMID: 28292314 PMC: 5351182. DOI: 10.1186/s12940-017-0233-5.

Social and Environmental Risk Factors for Hypertension in African Americans.

Rahman S, Hu H, McNeely E, Rahman S, Krieger N, Waterman P Fla Public Health Rev. 2009; 5:64-72.

PMID: 19966946 PMC: 2788965. DOI: 10.1901/jaba.2008.5-64.

A longitudinal study of chronic lead exposure and physical growth in Boston children.

Kim R, Hu H, Rotnitzky A, Bellinger D, Needleman H Environ Health Perspect. 1995; 103(10):952-7.

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Effects of chronic lead and cadmium exposure on blood pressure in occupationally exposed workers.

Schuhmacher M, Bosque M, Domingo J, Corbella J Biol Trace Elem Res. 1994; 41(3):269-78.

PMID: 7946918 DOI: 10.1007/BF02917428.

References

ROSE G, Blackburn H . Cardiovascular survey methods. Monogr Ser World Health Organ. 1968; 56:1-188. View

Delves H . A micro-sampling method for the rapid determination of lead in blood by atomic-absorption spectrophotometry. Analyst. 1970; 95(130):431-8. DOI: 10.1039/an9709500431. View

Speizer F, FERRIS Jr B . Exposure to antomobile exhaust. I. Prevalence of respiratory symptoms and disease. Arch Environ Health. 1973; 26(6):313-8. DOI: 10.1080/00039896.1973.10666289. View

Speizer F, FERRIS Jr B . Exposure to automobile exhaust. II. Pulmonary function measurements. Arch Environ Health. 1973; 26(6):319-24. DOI: 10.1080/00039896.1973.10666290. View

Burgess W, DiBerardinis L, Speizer F . Exposure to automobile exhaust. 3. An environmental assessment. Arch Environ Health. 1973; 26(6):325-9. DOI: 10.1080/00039896.1973.10666291. View

Jhaveri R, Lavorgna L, Dube S, Glass L, Khan F, Evans H . Relationship of blood pressure to blood lead concentrations in small children. Pediatrics. 1979; 63(4):674-6. View

Weiss S, Munoz A, Stein A, Sparrow D, Speizer F . The relationship of blood lead to blood pressure in a longitudinal study of working men. Am J Epidemiol. 1986; 123(5):800-8. DOI: 10.1093/oxfordjournals.aje.a114309. View

Mahaffey K, Annest J, Roberts J, Murphy R . National estimates of blood lead levels: United States, 1976-1980: association with selected demographic and socioeconomic factors. N Engl J Med. 1982; 307(10):573-9. DOI: 10.1056/NEJM198209023071001. View

McCarron D, Morris C, Henry H, Stanton J . Blood pressure and nutrient intake in the United States. Science. 1984; 224(4656):1392-8. DOI: 10.1126/science.6729459. View

10.

Pocock S, Shaper A, Ashby D, Delves T, Whitehead T . Blood lead concentration, blood pressure, and renal function. Br Med J (Clin Res Ed). 1984; 289(6449):872-4. PMC: 1443446. DOI: 10.1136/bmj.289.6449.872. View

11.

HARLAN W, Landis J, Schmouder R, Goldstein N, Harlan L . Blood lead and blood pressure. Relationship in the adolescent and adult US population. JAMA. 1985; 253(4):530-4. DOI: 10.1001/jama.253.4.530. View

12.

Pirkle J, Schwartz J, Landis J, HARLAN W . The relationship between blood lead levels and blood pressure and its cardiovascular risk implications. Am J Epidemiol. 1985; 121(2):246-58. DOI: 10.1093/oxfordjournals.aje.a113995. View

13.

Shaper A, Pocock S, Walker M, Wale C, Clayton B, Delves H . Effects of alcohol and smoking on blood lead in middle-aged British men. Br Med J (Clin Res Ed). 1982; 284(6312):299-302. PMC: 1495866. DOI: 10.1136/bmj.284.6312.299. View