Different Patterns of Left Ventricular Hypertrophy in Metabolically Healthy and Insulin-Resistant Obese Subjects

Overview

Journal Nutrients

Date 2020 Feb 9

PMID 32033349

Citations 8

Authors

Angela Sciacqua

Antonio Cimellaro

Luana Mancuso

Sofia Miceli

Velia Cassano

Maria Perticone

Teresa V Fiorentino

Francesco Andreozzi

Elena Succurro

Giorgio Sesti

Francesco Perticone

Affiliations

Soon will be listed here.

Abstract

Obese subjects showed different cardiovascular risk depending by different insulin sensitivity status. We investigated the difference in left ventricular mass and geometry between metabolically healthy (MHO) and unhealthy (MUHO) obese subjects. From a cohort of 876 obese subjects (48.3 ± 14.1 years) without cardio-metabolic disease and stratified according to increasing values of Matsuda index after 75 g oral glucose tolerance test, we defined MHO ( = 292) those in the upper tertile and MUHO ( = 292) those in the lower tertile. All participants underwent echocardiographic measurements. Left ventricular mass was calculated by Devereux equation and normalized by height and left ventricular hypertrophy (LVH) was defined by values >44 g/m for females and >48 g/m for males. Left ventricular geometric pattern was defined as concentric or eccentric if relative wall thickness was higher or lower than 0.42, respectively. MHO developed more commonly a concentric remodeling (19.9 vs. 9.9%; = 0.001) and had a reduced risk for LVH (OR 0.46; < 0.0001) than MUHO, in which the eccentric type was more prevalent (40.4 vs. 5.1%; < 0.0001). We demonstrated that obese subjects-matched for age, gender and BMI-have different left ventricular mass and geometry due to different insulin sensitivity status, suggesting that diverse metabolic phenotypes lead to alternative myocardial adaptation.

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