Antioxidant Activity of Compounds Isolated from Promotes Human Gingival Fibroblast Well-Being

Overview

Journal J Nat Prod

Date 2020 Feb 8

PMID 32031808

Citations 5

Authors

Anna Maria Iannuzzi

Chiara Giacomelli

Marinella De Leo

Deborah Pietrobono

Fabiano Camangi

Nunziatina De Tommasi

Claudia Martini

Maria Letizia Trincavelli

Alessandra Braca

Affiliations

Soon will be listed here.

Abstract

Four new triterpenoid bidesmosidic saponins (-) and a sesquiterpenoid glucoside (), together with nine known phenolic compounds (-), were isolated from the fruits of . Their structures were elucidated using 1D and 2D NMR spectroscopy and mass spectrometry data. The antioxidant capability of the isolated compounds was evaluated in human gingival fibroblasts. Compound decreased ROS production and promoted cell proliferation. It also counteracted the cell cycle blockade induced by a low concentration of HO decreasing the expression of p21 and CDKN2A (p16). Compound decreased the expression of inflammatory cytokines (IL-6 and IL-8) in response to inflammatory stimuli, supporting its possible use in periodontitis lesions.

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