Variation in the Lipin 1 Gene Is Associated with Birth Weight and Selected Carcass Traits in New Zealand Romney Sheep

Overview

Journal Animals (Basel)

Date 2020 Feb 8

PMID 32028610

Citations 4

Authors

Guan Wang

Huitong Zhou

Hua Gong

Jianning He

Yuzhu Luo

Jon G H Hickford

Jiang Hu

Jiqing Wang

Xiu Liu

Shaobin Li

Affiliations

Soon will be listed here.

Abstract

Lipin 1 plays an important role in lipid metabolism. In this study; we searched for variation in the ovine lipin 1 gene () in three gene regions (a 5' non-coding region; a region containing an alternatively spliced exon in intron 4; and a region containing coding exon 6) using polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis. The greatest amount of alleles was found in coding exon 6; with five sequences being detected. The effect of variation in this exon was investigated in 242 New Zealand Romney lambs derived from 12 sire-lines. The presence of variant was associated with a decrease in birth weight ( = 0.005) and the proportion of leg yield ( = 0.045), but with an increase in hot carcass weight ( = 0.032) and the proportion of loin yield ( = 0.014). The presence of variant was associated with an increased pre-weaning growth rate ( = 0.041), whereas the presence of variant was associated with an increase in shoulder yield ( < 0.001). These results suggest that ovine variation may have value as a genetic marker for improving meat production and carcass traits.

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