Recent Advances in the Development of Biosensors for Malaria Diagnosis

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2020 Feb 7

PMID 32024098

Citations 13

Authors

Francis D Krampa

Yaw Aniweh

Prosper Kanyong

Gordon A Awandare

Affiliations

Soon will be listed here.

Abstract

The impact of malaria on global health has continually prompted the need to develop more effective diagnostic strategies that could overcome deficiencies in accurate and early detection. In this review, we examine the various biosensor-based methods for malaria diagnostic biomarkers, namely; histidine-rich protein 2 (PfHRP-2), parasite lactate dehydrogenase (pLDH), aldolase, glutamate dehydrogenase (GDH), and the biocrystal hemozoin. The models that demonstrate a potential for field application have been discussed, looking at the fabrication and analytical performance characteristics, including (but not exclusively limited to): response time, sensitivity, detection limit, linear range, and storage stability, which are first summarized in a tabular form and then described in detail. The conclusion summarizes the state-of-the-art technologies applied in the field, the current challenges and the emerging prospects for malaria biosensors.

Citing Articles

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A simple polystyrene microfluidic device for sensitive and accurate SERS-based detection of infection by malaria parasites.

Oliveira M, Caetano S, Dalot A, Sabino F, Calmeiro T, Fortunato E Analyst. 2023; 148(17):4053-4063.

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Ultrasensitive electrochemical genosensors for species-specific diagnosis of malaria.

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Review of Microdevices for Hemozoin-Based Malaria Detection.

Baptista V, Peng W, Minas G, Veiga M, Catarino S Biosensors (Basel). 2022; 12(2).

PMID: 35200370 PMC: 8870200. DOI: 10.3390/bios12020110.

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