A Contemporary View on Felix Pinkus' Concept of the Vitreous Membrane

Overview

Journal Skin Appendage Disord

Specialty Dermatology

Date 2020 Feb 6

PMID 32021858

Authors

Karola Stieler

Annika Vogt

Wolfram Sterry

Norbert Haas

Ulrike Blume-Peytavi

Affiliations

Soon will be listed here.

Abstract

Introduction: Felix Pinkus' concept of the vitreous membrane (VM) published in 1927 describes circular folds protruding into the outer root sheath (ORS), which, in his opinion, serve as interdigitations between the outer root sheath (ORS) and the VM. This concept currently seems to have fallen into oblivion.

Objective: To determine the origin and possible function of the VM in the proliferation and vascularization of the hair follicle (HF).

Methods: Serial investigation of healthy skin probes with histological (hematoxylin & eosin and periodic acid-Schiff) and immunohistochemical examination (Ki67, CD56, CD8, and collagen IV) were performed.

Results: Morphological variations of the VM in various HFs such as protrusions and folds, the latter unilateral, bilateral or circular, some acute-angled, were found. Similarly, protrusions of the VM into the ORS were observed, that consisted of capillary tissue together with perifollicular tissue and VM mimicking minimal variants of the dermal papilla.

Conclusions: Pinkus' concept of the VM is revisited, reproduced and possible functions are proposed. Since these structures are found in a HF region with a high metabolic dynamism, they may be involved in differentiation or nutrition, or else be formed as a result of pressure arising from outgrowing hair shafts.

References

Gho C, Braun J, Tilli C, Neumann H, Ramaekers F . Human follicular stem cells: their presence in plucked hair and follicular cell culture. Br J Dermatol. 2004; 150(5):860-8. DOI: 10.1111/j.1365-2133.2004.05862.x. View

Botchkarev V, Eichmuller S, Johansson O, Paus R . Hair cycle-dependent plasticity of skin and hair follicle innervation in normal murine skin. J Comp Neurol. 1997; 386(3):379-95. DOI: 10.1002/(sici)1096-9861(19970929)386:3<379::aid-cne4>3.0.co;2-z. View

Horak E, Leek R, Klenk N, Lejeune S, Smith K, Stuart N . Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet. 1992; 340(8828):1120-4. DOI: 10.1016/0140-6736(92)93150-l. View

Schadendorf D, Tiedemann K, Haas N, Czarnetzki B . Detection of human papillomaviruses in paraffin-embedded condylomata acuminata--comparison of immunohistochemistry, in situ hybridization, and polymerase chain reaction. J Invest Dermatol. 1991; 97(3):549-54. DOI: 10.1111/1523-1747.ep12481884. View

Lyle S, Christofidou-Solomidou M, Liu Y, Elder D, Albelda S, Cotsarelis G . The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci. 1998; 111 ( Pt 21):3179-88. DOI: 10.1242/jcs.111.21.3179. View

Messenger A, Elliott K, Westgate G, Gibson W . Distribution of extracellular matrix molecules in human hair follicles. Ann N Y Acad Sci. 1991; 642:253-62. DOI: 10.1111/j.1749-6632.1991.tb24392.x. View

Poblet E, Jimenez-Acosta F, Rocamora A . QBEND/10 (anti-CD34 antibody) in external root sheath cells and follicular tumors. J Cutan Pathol. 1994; 21(3):224-8. DOI: 10.1111/j.1600-0560.1994.tb00264.x. View

Trempus C, Morris R, Bortner C, Cotsarelis G, Faircloth R, Reece J . Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol. 2003; 120(4):501-11. DOI: 10.1046/j.1523-1747.2003.12088.x. View

Cotsarelis G, Sun T, Lavker R . Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell. 1990; 61(7):1329-37. DOI: 10.1016/0092-8674(90)90696-c. View

10.

Chuang Y, Dean D, Allen J, Dawber R, Wojnarowska F . Comparison between the expression of basement membrane zone antigens of human interfollicular epidermis and anagen hair follicle using indirect immunofluorescence. Br J Dermatol. 2003; 149(2):274-81. DOI: 10.1046/j.1365-2133.2003.05468.x. View

11.

Guesdon J, Ternynck T, Avrameas S . The use of avidin-biotin interaction in immunoenzymatic techniques. J Histochem Cytochem. 1979; 27(8):1131-9. DOI: 10.1177/27.8.90074. View

12.

Horne K, Jahoda C . Restoration of hair growth by surgical implantation of follicular dermal sheath. Development. 1992; 116(3):563-71. DOI: 10.1242/dev.116.3.563. View

13.

Wollina U . Histochemistry of the human hair follicle with consideration of anagen phases I to VI. Acta Histochem. 1992; 92(2):171-8. DOI: 10.1016/S0065-1281(11)80078-4. View

14.

Jih D, Lyle S, Elenitsas R, Elder D, Cotsarelis G . Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells. J Cutan Pathol. 1999; 26(3):113-8. DOI: 10.1111/j.1600-0560.1999.tb01814.x. View

15.

Sun T, Cotsarelis G, Lavker R . Hair follicular stem cells: the bulge-activation hypothesis. J Invest Dermatol. 1991; 96(5):77S-78S. DOI: 10.1111/1523-1747.ep12471959. View

16.

Jahoda C, Mauger A, BARD S, Sengel P . Changes in fibronectin, laminin and type IV collagen distribution relate to basement membrane restructuring during the rat vibrissa follicle hair growth cycle. J Anat. 1992; 181 ( Pt 1):47-60. PMC: 1259751. View

17.

Mecklenburg L, Tobin D, Muller-Rover S, Handjiski B, Wendt G, Peters E . Active hair growth (anagen) is associated with angiogenesis. J Invest Dermatol. 2000; 114(5):909-16. DOI: 10.1046/j.1523-1747.2000.00954.x. View

18.

Weber L, Krieg T, Muller P, KIRSCH E, Timpl R . Immunofluorescent localization of type IV collagen and laminin in human skin and its application in junctional zone pathology. Br J Dermatol. 1982; 106(3):267-73. DOI: 10.1111/j.1365-2133.1982.tb01722.x. View

19.

Braun-Falco O . [Dynamics of normal and pathological hair growth]. Arch Klin Exp Dermatol. 1966; 227(1):419-52. DOI: 10.1007/BF00502868. View