Comparison of the Genomic Profile of Cancer Stem Cells and Their Non-Stem Counterpart: The Case of Ovarian Cancer

Overview

Journal J Clin Med

Specialty General Medicine

Date 2020 Feb 5

PMID 32013179

Citations 3

Authors

Elena Laura Mazzoldi

Anna Pasto

Giorgia Pilotto

Sonia Minuzzo

Ilaria Piga

Pietro Palumbo

Massimo Carella

Simona Frezzini

Maria Ornella Nicoletto

Alberto Amadori

Stefano Indraccolo

Affiliations

Soon will be listed here.

Abstract

The classical cancer stem cell (CSC) model places CSCs at the apex of a hierarchical scale, suggesting different genetic alterations in non-CSCs compared to CSCs, since an ill-defined number of cell generations and time intervals separate CSCs from the more differentiated cancer cells that form the bulk of the tumor. Another model, however, poses that CSCs should be considered a functional state of tumor cells, hence sharing the same genetic alterations. Here, we review the existing literature on the genetic landscape of CSCs in various tumor types and as a case study investigate the genomic complexity of DNA obtained from matched CSCs and non-CSCs from five ovarian cancer patients, using a genome-wide single-nucleotide polymorphism (SNP) microarray.

Citing Articles

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