The Toxicological Intersection Between Allergen and Toxin: A Structural Comparison of the Cat Dander Allergenic Protein Fel D1 and the Slow Loris Brachial Gland Secretion Protein

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2020 Feb 5

PMID 32012831

Citations 9

Authors

Holger Scheib

K Anne-Isola Nekaris

Johanna Rode-Margono

Lotten Ragnarsson

Kate Baumann

James S Dobson

Wirdateti Wirdateti

Amanda Nouwens

Vincent Nijman

Paolo Martelli

Rui Ma

Richard J Lewis

Hang Fai Kwok

Bryan Grieg Fry

Affiliations

Soon will be listed here.

Abstract

Slow lorises are enigmatic animal that represent the only venomous primate lineage. Their defensive secretions have received little attention. In this study we determined the full length sequence of the protein secreted by their unique brachial glands. The full length sequences displayed homology to the main allergenic protein present in cat dander. We thus compared the molecular features of the slow loris brachial gland protein and the cat dander allergen protein, showing remarkable similarities between them. Thus we postulate that allergenic proteins play a role in the slow loris defensive arsenal. These results shed light on these neglected, novel animals.

Citing Articles

Genetic diversity of the major cat allergen, Fel d 1.

Cleveland 3rd C, Davis B, Khatri K, Pomes A, Chapman M, Brackett N PNAS Nexus. 2024; 3(11):pgae447.

PMID: 39600803 PMC: 11577610. DOI: 10.1093/pnasnexus/pgae447.

Anaphylaxis following a slow loris bite occurring in an area of forest fragmentation.

Muldani A, Llano Sanchez K, Farey K BMJ Case Rep. 2024; 17(11).

PMID: 39581684 PMC: 11590447. DOI: 10.1136/bcr-2024-260219.

Evaluation of anti-Fel d 1 IgY ingredient for pet food on growth performance in kittens.

Hedrick E, Matulka R, Conboy-Schmidt L, May K Front Vet Sci. 2024; 11:1355390.

PMID: 38505000 PMC: 10948519. DOI: 10.3389/fvets.2024.1355390.

Slowly Making Sense: A Review of the Two-Step Venom System within Slow ( spp.) and Pygmy Lorises ( spp.).

Fitzpatrick L, Ligabue-Braun R, Nekaris K Toxins (Basel). 2023; 15(9).

PMID: 37755940 PMC: 10536643. DOI: 10.3390/toxins15090514.

The Fast and the Furriest: Investigating the Rate of Selection on Mammalian Toxins.

Fitzpatrick L, Nijman V, Ligabue-Braun R, Nekaris K Toxins (Basel). 2022; 14(12).

PMID: 36548740 PMC: 9782207. DOI: 10.3390/toxins14120842.

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