Dissecting the Vesicular Trafficking Function of IFT Subunits

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2020 Feb 4

PMID 32010685

Citations 7

Authors

Huihui Yang

Kaiyao Huang

Affiliations

Soon will be listed here.

Abstract

Intraflagellar transport (IFT) was initially identified as a transport machine with multiple protein subunits, and it is essential for the assembly, disassembly, and maintenance of cilium/flagellum, which serves as the nexus of extracellular-to-intracellular signal integration. To date, in addition to its well-established and indispensable roles in ciliated cells, most IFT subunits have presented more general functions of vesicular trafficking in the non-ciliated cells. Thus, this review aims to summarize the recent progress on the vesicular trafficking functions of the IFT subunits and to highlight the issues that may arise in future research.

Citing Articles

The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans.

Brinzer R, Winter A, Page A G3 (Bethesda). 2024; 14(3).

PMID: 38227795 PMC: 10917524. DOI: 10.1093/g3journal/jkae009.

Ciliogenesis membrane dynamics and organization.

Zhao H, Khan Z, Westlake C Semin Cell Dev Biol. 2022; 133:20-31.

PMID: 35351373 PMC: 9510604. DOI: 10.1016/j.semcdb.2022.03.021.

Male infertility-associated Ccdc108 regulates multiciliogenesis via the intraflagellar transport machinery.

Zhao H, Sun J, Insinna C, Lu Q, Wang Z, Nagashima K EMBO Rep. 2022; 23(4):e52775.

PMID: 35201641 PMC: 8982597. DOI: 10.15252/embr.202152775.

Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E.

Dewees S, Vargova R, Hardin K, Turn R, Devi S, Linnert J Mol Biol Cell. 2022; 33(4):ar33.

PMID: 35196065 PMC: 9250359. DOI: 10.1091/mbc.E21-10-0509-T.

Recent advances in understanding assembly of the primary cilium membrane.

Shakya S, Westlake C Fac Rev. 2021; 10:16.

PMID: 33718933 PMC: 7946393. DOI: 10.12703/r/10-16.

References

Heider M, Gu M, Duffy C, Mirza A, Marcotte L, Walls A . Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Nat Struct Mol Biol. 2015; 23(1):59-66. PMC: 4752824. DOI: 10.1038/nsmb.3146. View

Han Y, Kim H, Dlugosz A, Ellison D, Gilbertson R, Alvarez-Buylla A . Dual and opposing roles of primary cilia in medulloblastoma development. Nat Med. 2009; 15(9):1062-5. PMC: 2771737. DOI: 10.1038/nm.2020. View

Fliegauf M, Benzing T, Omran H . When cilia go bad: cilia defects and ciliopathies. Nat Rev Mol Cell Biol. 2007; 8(11):880-93. DOI: 10.1038/nrm2278. View

Kitami M, Yamaguchi H, Ebina M, Kaku M, Chen D, Komatsu Y . IFT20 is required for the maintenance of cartilaginous matrix in condylar cartilage. Biochem Biophys Res Commun. 2018; 509(1):222-226. PMC: 6443088. DOI: 10.1016/j.bbrc.2018.12.107. View

Vuong L, Iomini C, Balmer S, Esposito D, Aaronson S, Mlodzik M . Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling. Nat Commun. 2018; 9(1):5304. PMC: 6294004. DOI: 10.1038/s41467-018-07605-z. View

Ou G, Blacque O, Snow J, Leroux M, Scholey J . Functional coordination of intraflagellar transport motors. Nature. 2005; 436(7050):583-7. DOI: 10.1038/nature03818. View

Broekhuis J, Rademakers S, Burghoorn J, Jansen G . SQL-1, homologue of the Golgi protein GMAP210, modulates intraflagellar transport in C. elegans. J Cell Sci. 2013; 126(Pt 8):1785-95. DOI: 10.1242/jcs.116640. View

Wei Q, Zhang Y, Li Y, Zhang Q, Ling K, Hu J . The BBSome controls IFT assembly and turnaround in cilia. Nat Cell Biol. 2012; 14(9):950-7. PMC: 3434251. DOI: 10.1038/ncb2560. View

Sancho D, Vicente-Manzanares M, Mittelbrunn M, Montoya M, Gordon-Alonso M, Serrador J . Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions. Immunol Rev. 2002; 189:84-97. DOI: 10.1034/j.1600-065x.2002.18908.x. View

10.

Field M, Sali A, Rout M . Evolution: On a bender--BARs, ESCRTs, COPs, and finally getting your coat. J Cell Biol. 2011; 193(6):963-72. PMC: 3115789. DOI: 10.1083/jcb.201102042. View

11.

Hua K, Ferland R . Primary Cilia Reconsidered in the Context of Ciliopathies: Extraciliary and Ciliary Functions of Cilia Proteins Converge on a Polarity theme?. Bioessays. 2018; 40(8):e1700132. PMC: 6239423. DOI: 10.1002/bies.201700132. View

12.

Bonello G, Blanchard N, Montoya M, Aguado E, Langlet C, He H . Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment. J Cell Sci. 2004; 117(Pt 7):1009-16. DOI: 10.1242/jcs.00968. View

13.

Bernabe-Rubio M, Andres G, Casares-Arias J, Fernandez-Barrera J, Rangel L, Reglero-Real N . Novel role for the midbody in primary ciliogenesis by polarized epithelial cells. J Cell Biol. 2016; 214(3):259-73. PMC: 4970324. DOI: 10.1083/jcb.201601020. View

14.

Pedersen L, Miller M, Geimer S, Leitch J, Rosenbaum J, Cole D . Chlamydomonas IFT172 is encoded by FLA11, interacts with CrEB1, and regulates IFT at the flagellar tip. Curr Biol. 2005; 15(3):262-6. DOI: 10.1016/j.cub.2005.01.037. View

15.

Vieira O, Gaus K, Verkade P, Fullekrug J, Vaz W, Simons K . FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells. Proc Natl Acad Sci U S A. 2006; 103(49):18556-61. PMC: 1693701. DOI: 10.1073/pnas.0608291103. View

16.

Martin-Cofreces N, Robles-Valero J, Cabrero J, Mittelbrunn M, Gordon-Alonso M, Sung C . MTOC translocation modulates IS formation and controls sustained T cell signaling. J Cell Biol. 2008; 182(5):951-62. PMC: 2528574. DOI: 10.1083/jcb.200801014. View

17.

Liew G, Ye F, Nager A, Murphy J, Lee J, Aguiar M . The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev Cell. 2014; 31(3):265-278. PMC: 4255629. DOI: 10.1016/j.devcel.2014.09.004. View

18.

Kim S, Tsiokas L . Cilia and cell cycle re-entry: more than a coincidence. Cell Cycle. 2011; 10(16):2683-90. PMC: 3219538. DOI: 10.4161/cc.10.16.17009. View

19.

Long H, Zhang F, Xu N, Liu G, Diener D, Rosenbaum J . Comparative Analysis of Ciliary Membranes and Ectosomes. Curr Biol. 2016; 26(24):3327-3335. PMC: 5173405. DOI: 10.1016/j.cub.2016.09.055. View

20.

Jonassen J, San Agustin J, Follit J, Pazour G . Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol. 2008; 183(3):377-84. PMC: 2575779. DOI: 10.1083/jcb.200808137. View