Effect of Neuromedin U on Allergic Airway Inflammation in an Asthma Model

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2020 Feb 4

PMID 32010240

Citations 4

Authors

Xiaojie Ren

Fang Dong

Yuerong Zhuang

Yong Wang

Wuhua Ma

Affiliations

Soon will be listed here.

Abstract

Asthma is a major inflammatory airway disease with high incidence and mortality rates. The Global Initiative for Asthma released a report called 'The Global Burden of Asthma' in 2004. However, the specific pathogenesis of asthma remains unclear. An increasing number of studies have demonstrated that neuromedin U (NMU) plays a pleiotropic role in the pathogenesis of asthma. NMU is a highly structurally conserved neuropeptide that was first purified from porcine spinal cord and named for its contractile effect on the rat uterus. NMU amplifies type 2 innate lymphoid cell (ILC2)-driven allergic lung inflammation. The NMU receptors (NMURs), designated as NMUR1 and NMUR2, belong to the G protein-coupled receptor family. NMUR1 has also been found in immune cells, including ILC2s, mast cells and eosinophils. In view of the important roles of NMU in the pathogenesis of asthma, the present review evaluates the potential mechanisms underlying the impact of NMU on asthma and its association with asthma therapy.

Citing Articles

A genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD.

Do A, An J, Jo J, Kim W, Kang H, Lee S Sci Rep. 2022; 12(1):22073.

PMID: 36543808 PMC: 9772307. DOI: 10.1038/s41598-022-24766-6.

Neuronal-Immune Cell Units in Allergic Inflammation in the Nose.

Klimov V, Cherevko N, Klimov A, Novikov P Int J Mol Sci. 2022; 23(13).

PMID: 35805946 PMC: 9266453. DOI: 10.3390/ijms23136938.

Neuromedins NMU and NMS: An Updated Overview of Their Functions.

Malendowicz L, Rucinski M Front Endocrinol (Lausanne). 2021; 12:713961.

PMID: 34276571 PMC: 8283259. DOI: 10.3389/fendo.2021.713961.

Neuroimmune regulatory networks of the airway mucosa in allergic inflammatory disease.

Jean E, Good O, Rico J, Rossi H, Herbert D J Leukoc Biol. 2021; 111(1):209-221.

PMID: 33857344 PMC: 8674821. DOI: 10.1002/JLB.3RU0121-023R.

References

Alfa R, Park S, Skelly K, Poffenberger G, Jain N, Gu X . Suppression of insulin production and secretion by a decretin hormone. Cell Metab. 2015; 21(2):323-334. PMC: 4349554. DOI: 10.1016/j.cmet.2015.01.006. View

Cording S, Medvedovic J, Aychek T, Eberl G . Innate lymphoid cells in defense, immunopathology and immunotherapy. Nat Immunol. 2016; 17(7):755-7. DOI: 10.1038/ni.3448. View

Johnson E, Appelbaum E, Carpenter D, Cox R, Disa J, Foley J . Neuromedin U elicits cytokine release in murine Th2-type T cell clone D10.G4.1. J Immunol. 2004; 173(12):7230-8. DOI: 10.4049/jimmunol.173.12.7230. View

Ni D, Gu Q, Hu H, Gao N, Zhu M, Lee L . Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors. Am J Physiol Regul Integr Comp Physiol. 2006; 291(3):R541-50. DOI: 10.1152/ajpregu.00016.2006. View

Bal S, Bernink J, Nagasawa M, Groot J, Shikhagaie M, Golebski K . IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs. Nat Immunol. 2016; 17(6):636-45. DOI: 10.1038/ni.3444. View

Ray A, Raundhal M, Oriss T, Ray P, Wenzel S . Current concepts of severe asthma. J Clin Invest. 2016; 126(7):2394-403. PMC: 4922699. DOI: 10.1172/JCI84144. View

Borchers M, Justice P, Ansay T, Mancino V, McGarry M, Crosby J . Gq signaling is required for allergen-induced pulmonary eosinophilia. J Immunol. 2002; 168(7):3543-9. DOI: 10.4049/jimmunol.168.7.3543. View

Hoogerwerf W, Zou L, Shenoy M, Sun D, Micci M, Xiao S . The proteinase-activated receptor 2 is involved in nociception. J Neurosci. 2001; 21(22):9036-42. PMC: 6762290. View

Martinez V, ODriscoll L . Neuromedin U: a multifunctional neuropeptide with pleiotropic roles. Clin Chem. 2015; 61(3):471-82. DOI: 10.1373/clinchem.2014.231753. View

10.

Mitchell J, Maguire J, Davenport A . Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S. Br J Pharmacol. 2009; 158(1):87-103. PMC: 2795236. DOI: 10.1111/j.1476-5381.2009.00252.x. View

11.

Theiler A, Barnthaler T, Platzer W, Richtig G, Peinhaupt M, Rittchen S . Butyrate ameliorates allergic airway inflammation by limiting eosinophil trafficking and survival. J Allergy Clin Immunol. 2019; 144(3):764-776. DOI: 10.1016/j.jaci.2019.05.002. View

12.

Mesnil C, Raulier S, Paulissen G, Xiao X, Birrell M, Pirottin D . Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J Clin Invest. 2016; 126(9):3279-95. PMC: 5004964. DOI: 10.1172/JCI85664. View

13.

Fang L, Zhang M, Li C, Dong S, Hu Y . Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones. Neurosci Lett. 2006; 404(1-2):148-53. DOI: 10.1016/j.neulet.2006.05.034. View

14.

Pascoe S, Locantore N, Dransfield M, Barnes N, Pavord I . Blood eosinophil counts, exacerbations, and response to the addition of inhaled fluticasone furoate to vilanterol in patients with chronic obstructive pulmonary disease: a secondary analysis of data from two parallel randomised controlled trials. Lancet Respir Med. 2015; 3(6):435-42. DOI: 10.1016/S2213-2600(15)00106-X. View

15.

Canning B, Spina D . Sensory nerves and airway irritability. Handb Exp Pharmacol. 2009; (194):139-83. PMC: 7120605. DOI: 10.1007/978-3-540-79090-7_5. View

16.

Sugita K, Steer C, Martinez-Gonzalez I, Altunbulakli C, Morita H, Castro-Giner F . Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients. J Allergy Clin Immunol. 2017; 141(1):300-310.e11. DOI: 10.1016/j.jaci.2017.02.038. View

17.

Bateman E, Hurd S, Barnes P, Bousquet J, Drazen J, Fitzgerald J . Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008; 31(1):143-78. DOI: 10.1183/09031936.00138707. View

18.

Zhang Y, Jiang D, Zhang Y, Jiang X, Wang F, Tao J . Neuromedin U type 1 receptor stimulation of A-type K+ current requires the βγ subunits of Go protein, protein kinase A, and extracellular signal-regulated kinase 1/2 (ERK1/2) in sensory neurons. J Biol Chem. 2012; 287(22):18562-72. PMC: 3365707. DOI: 10.1074/jbc.M111.322271. View

19.

Lee J, Snyder E, Liu Y, Gu X, Wang J, Flowers B . Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells. Nat Commun. 2017; 8:14686. PMC: 5344977. DOI: 10.1038/ncomms14686. View

20.

Howard A, Wang R, Pong S, Mellin T, Strack A, Guan X . Identification of receptors for neuromedin U and its role in feeding. Nature. 2000; 406(6791):70-4. DOI: 10.1038/35017610. View