Getting into Position: Nuclear Movement in Muscle Cells

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2020 Feb 4

PMID 32008895

Citations 26

Authors

Mafalda Azevedo

Mary K Baylies

Affiliations

Soon will be listed here.

Abstract

The positioning of nuclei within the cell is a dynamic process that depends on the cell's fate and developmental stage and that is adjusted for optimal cell function. This is especially true in skeletal muscle cells, which contain hundreds of myonuclei distributed evenly along the periphery of the muscle cell. Mispositioned myonuclei are often associated with muscle dysfunction and disease. Different mechanisms governing myonuclear positioning are now emerging, with several of the new genes implicated in nuclear movement linked to human muscle disease. Here we discuss the recent advances in myonuclear positioning and its implications for muscle size and function from the view of Drosophila. Additionally, we highlight similarities and differences to mammalian systems and provide connections to human muscle disease.

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