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Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A

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Date 2020 Feb 3
PMID 32007299
Citations 14
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Abstract

Serum amyloid A (SAA) is a marker of inflammation and infection in the horse that can be assessed in the field, with rapid and marked changes seen following initiation of an inflammatory stimulus. This quality of SAA also makes its clinical use challenging, because even small inflammatory conditions can cause large changes in SAA levels. Review of the current literature provides guidelines for responses of SAA to various conditions, which can be applied to specific clinical cases. The practitioner is encouraged to use SAA in conjunction with physical examination and other diagnostic modalities to guide treatment and monitor case progression.

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References
1.
Pepys M, Baltz M, Tennent G, Kent J, Ousey J, Rossdale P . Serum amyloid A protein (SAA) in horses: objective measurement of the acute phase response. Equine Vet J. 1989; 21(2):106-9. DOI: 10.1111/j.2042-3306.1989.tb02108.x. View

2.
Witkowska-Pilaszewicz O, Zmigrodzka M, Winnicka A, Miskiewicz A, Strzelec K, Cywinska A . Serum amyloid A in equine health and disease. Equine Vet J. 2018; 51(3):293-298. PMC: 7163734. DOI: 10.1111/evj.13062. View

3.
Menzies-Gow N, Wray H, Bailey S, Harris P, Elliott J . The effect of exercise on plasma concentrations of inflammatory markers in normal and previously laminitic ponies. Equine Vet J. 2013; 46(3):317-21. DOI: 10.1111/evj.12132. View

4.
Kristensen L, Buhl R, Nostell K, Bak L, Petersen E, Lindholm M . Acute exercise does not induce an acute phase response (APR) in Standardbred trotters. Can J Vet Res. 2014; 78(2):97-102. PMC: 3962284. View

5.
Labelle A, Hamor R, MacNeill A, Lascola K, Breaux C, Tolar E . Effects of ophthalmic disease on concentrations of plasma fibrinogen and serum amyloid A in the horse. Equine Vet J. 2011; 43(4):460-5. DOI: 10.1111/j.2042-3306.2010.00305.x. View