Merkel Cell Polyomavirus Detected in Head and Neck Carcinomas from Chile

Overview

Journal Infect Agent Cancer

Publisher Biomed Central

Specialty Infectious Diseases

Date 2020 Feb 1

PMID 32002023

Citations 6

Authors

Juan P Munoz

Rances Blanco

Julio C Osorio

Carolina Oliva

Maria Jose Diaz

Diego Carrillo-Beltran

Rebeca Aguayo

Andres Castillo

Julio C Tapia

Gloria M Calaf

Aldo Gaggero

Francisco Aguayo

Affiliations

Soon will be listed here.

Abstract

Background: The role of human polyomaviruses (HPyVs) in epithelial tumors such as head and neck carcinomas (HNSCCs) including oral and oropharyngeal carcinomas has not been established. In this study, we evaluated for the first time the presence of Merkel cell polyomavirus (MCPyV), BK human polyomavirus (BKPyV), and JC human polyomavirus (JCPyV) in HNSCCs from Chilean subjects.

Methods: One hundred and twenty HNSCCs were analyzed for the presence of MCPyV, BKPyV and JCPyV using real-time polymerase chain reaction procedures. In addition, 54 oral brushes from age- and sex-paired subjects were analyzed.

Results: Of the total of 120 HNSCCs, 15 were positive for MCPyV (12.5%). Only one case was positive for BKPyV (0.8%) and none for JCPyV (0%). In subjects without cancer, only one case (1.8%) resulted positive for MCPyV and none for JCPyV and BKPyV. MCPyV was associated with HNSCCs ( = 0.0239; OR = 7.571; 95% CI: 1.192-81.46). No association was found between age ( = 0.1996), gender ( = 0.7111) or differentiation status ( > 0.9999) and MCPyV presence in HNSCCs.

Conclusions: MCPyVs were detected in HNSCCs from Chilean patients and were not detected in oral brushes from patients without cancer. More studies are warranted for defining an etiological role and clinical/molecular consequences of these viruses in HNSCCs.

Citing Articles

The Role of Oncogenic Viruses in Head and Neck Cancers: Epidemiology, Pathogenesis, and Advancements in Detection Methods.

Samara P, Athanasopoulos M, Mastronikolis S, Kyrodimos E, Athanasopoulos I, Mastronikolis N Microorganisms. 2024; 12(7).

PMID: 39065250 PMC: 11279059. DOI: 10.3390/microorganisms12071482.

Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders.

Passerini S, Babini G, Merenda E, Carletti R, Scribano D, Rosa L Biomedicines. 2024; 12(4).

PMID: 38672065 PMC: 11047982. DOI: 10.3390/biomedicines12040709.

Detection of Merkel cell polyomavirus in multiple primary oral squamous cell carcinomas.

Kitamura N, Hashida Y, Higuchi T, Ohno S, Sento S, Sasabe E Odontology. 2023; 111(4):971-981.

PMID: 36964865 PMC: 10492774. DOI: 10.1007/s10266-023-00807-y.

Prevalence of Co-infection by Human Papillomavirus, Epstein- Barr Virus and Merkel Cell Polyomavirus in Iranian Oral Cavity Cancer and Pre-malignant Lesions.

Saber Amoli S, Hasanzadeh A, Sadeghi F, Chehrazi M, Seyedmajidi M, Zebardast A Int J Mol Cell Med. 2022; 11(1):64-77.

PMID: 36397808 PMC: 9653548. DOI: 10.22088/IJMCM.BUMS.11.1.64.

Characterization of High-Risk HPV/EBV Co-Presence in Pre-Malignant Cervical Lesions and Squamous Cell Carcinomas.

Blanco R, Carrillo-Beltran D, Munoz J, Osorio J, Tapia J, Burzio V Microorganisms. 2022; 10(5).

PMID: 35630333 PMC: 9144326. DOI: 10.3390/microorganisms10050888.

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