MECHANISMS IN ENDOCRINOLOGY: Autoimmune Hypopituitarism: Novel Mechanistic Insights

Overview

Journal Eur J Endocrinol

Publisher Oxford University Press

Specialty Endocrinology

Date 2020 Jan 31

PMID 31999621

Citations 16

Authors

Yutaka Takahashi

Affiliations

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Abstract

Hypopituitarism is caused by various insults to the pituitary, such as hypothalamic and pituitary tumors, inflammation, autoimmunity, vascular injury, genetic abnormalities, irradiation, and trauma. Recently, it has been found that autoimmunity to the pituitary involves many pathological conditions associated with specific or non-specific hormone deficiencies in the gland. This review discusses the recent findings on the underlying mechanism of autoimmune hypopituitarism particularly of lymphocytic hypophysitis, IgG4-related hypophysitis, immune checkpoint inhibitor-induced hypophysitis, anti-PIT-1 hypophysitis, and isolated ACTH deficiency.

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A case of IgG4-related hypophysitis maintained remission of diabetes insipidus for over 3 months after completion of steroid treatment.

Kubori M, Fujimoto M, Okauchi Y, Matsuno K, Yamabayashi E, Sakamoto R Endocrinol Diabetes Metab Case Rep. 2023; 2023(4).

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