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Genetic Variability of the AcrAB-TolC Multidrug Efflux Pump Underlies SkQ1 Resistance in Gram-Negative Bacteria

Overview
Journal Acta Naturae
Specialty Biology
Date 2020 Jan 30
PMID 31993240
Citations 10
Authors
P A Nazarov
E A Kotova
V P Skulachev
Y N Antonenko
Affiliations
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Abstract

SkQ1, a novel antibiotic targeting bacterial bioenergetics, is highly effective against both gram-positive and gram-negative bacteria. However, some gram-negative bacteria, such as and , are highly resistant to it. In different gram-negative bacteria, this resistance is associated with the identity of their AcrB transporter protein sequence with the sequence of the AcrB protein from . SkQ1 is expelled from cells by the AcrAB-TolC multidrug efflux pump. In this study, we demonstrate that SkQ1 resistance in , in contrast to chloramphenicol resistance, does not depend on the presence of the multidrug efflux pump accessory protein AcrZ.

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