Role of Carotenoids and Retinoids During Heart Development

Overview

Journal Biochim Biophys Acta Mol Cell Biol Lipids

Publisher Elsevier

Specialties Biochemistry
Biophysics
Cell Biology

Date 2020 Jan 25

PMID 31978553

Citations 13

Authors

Ioan Ovidiu Sirbu

Aimee Rodica Chis

Alexander Radu Moise

Affiliations

Soon will be listed here.

Abstract

The nutritional requirements of the developing embryo are complex. In the case of dietary vitamin A (retinol, retinyl esters and provitamin A carotenoids), maternal derived nutrients serve as precursors to signaling molecules such as retinoic acid, which is required for embryonic patterning and organogenesis. Despite variations in the composition and levels of maternal vitamin A, embryonic tissues need to generate a precise amount of retinoic acid to avoid congenital malformations. Here, we summarize recent findings regarding the role and metabolism of vitamin A during heart development and we survey the association of genes known to affect retinoid metabolism or signaling with various inherited disorders. A better understanding of the roles of vitamin A in the heart and of the factors that affect retinoid metabolism and signaling can help design strategies to meet nutritional needs and to prevent birth defects and disorders associated with altered retinoid metabolism. This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro.

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