Long-term Observation of Rats After Unilateral Intra-amygdaloid Injection of Kainic Acid

Overview

Journal Brain Res

Specialty Neurology

Date 1988 Oct 25

PMID 3196905

Citations 9

Authors

S Tanaka

S Kondo

T Tanaka

Y Yonemasu

Affiliations

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Abstract

Electroencephalographic and clinical observations of the rats were done for 3 months after microinjection of kainic acid (KA, 0.2-1.2 micrograms) into the unilateral amygdala. With high doses of KA (0.6-1.2 micrograms) injection, 64% of rats developed spontaneous limbic seizures 14-25 days after KA injection. Among those which developed spontaneous limbic seizures, 33% of rats developed secondarily generalized seizures 26-71 days after KA injection. This is one of the best chronic models of spontaneous complex partial seizure secondarily generalized in rats, which is economical and easy to prepare.

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