Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Overview

Journal Nutrients

Date 2020 Jan 23

PMID 31963885

Citations 29

Authors

Sok Kuan Wong

Yusof Kamisah

Norazlina Mohamed

Norliza Muhammad

Norliana Masbah

Nur Azlina Mohd Fahami

Isa Naina Mohamed

Ahmad Nazun Shuid

Qodriyah Mohd Saad

Azman Abdullah

Nur-Vaizura Mohamad

Nurul Izzah Ibrahim

Kok-Lun Pang

Yoke Yue Chow

Benjamin Ka Seng Thong

Shaanthana Subramaniam

Chin Yi Chan

Soelaiman Ima-Nirwana

And Kok-Yong Chin

Affiliations

Soon will be listed here.

Abstract

Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.

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