Use of Medications by Breastfeeding Women in the 2015 Pelotas (Brazil) Birth Cohort Study

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2020 Jan 23

PMID 31963112

Citations 6

Authors

Barbara Heather Lutz

Diego Garcia Bassani

Vanessa Iribarrem Avena Miranda

Marysabel Pinto Telis Silveira

Sotero Serrate Mengue

Tatiane da Silva Dal Pizzol

Mariangela Freitas da Silveira

Andrea Damaso Bertoldi

Affiliations

Soon will be listed here.

Abstract

This study describes medication use by women up to 3 months postpartum and evaluates the association between medication use by women who were still breastfeeding at 3 months postpartum and weaning at 6 and 12 months. Population-based cohort, including women who breastfed ( = 3988). Medications were classified according to Hale's lactation risk categories and Brazilian Ministry of Health criteria. Duration of breastfeeding was analysed using Cox regression models and Kaplan-Meier curves, including only women who were still breastfeeding at three months postpartum. Medication use with some risk for lactation was frequent (79.6% regarding Hale's risk categories and 12.3% regarding Brazilian Ministry of Health criteria). We did not find statistically significant differences for weaning at 6 or 12 months between the group who did not use medication or used only compatible medications and the group who used medications with some risk for lactation, according to both criteria. Our study found no association between weaning rates across the different breastfeeding safety categories of medications in women who were still breastfeeding at three months postpartum. Therefore, women who took medications and stopped breastfeeding in the first three months postpartum because of adverse side-effects associated with medications could not be addressed in this analysis.

Citing Articles

The use of prescription medications and non-prescription medications during lactation in a prospective Canadian cohort study.

Soliman Y, Yakandawala U, Leong C, Garlock E, Brinkman F, Winsor G Int Breastfeed J. 2024; 19(1):23.

PMID: 38589955 PMC: 11000278. DOI: 10.1186/s13006-024-00628-x.

Medicines postpartum in Sweden and coverage in Janusmed Breastfeeding.

Asplund A, Skold P, Lind L, Cesta C, Dahl M, Jonsson E Eur J Clin Pharmacol. 2023; 79(9):1261-1269.

PMID: 37452835 PMC: 10427528. DOI: 10.1007/s00228-023-03528-x.

Medication Intake as a Factor for Non-Initiation and Cessation of Breastfeeding: A Prospective Cohort Study in Greece during the COVID-19 Pandemic.

Tigka M, Metallinou D, Nanou C, Iliodromiti Z, Gryparis A, Lykeridou K Children (Basel). 2023; 10(3).

PMID: 36980144 PMC: 10047701. DOI: 10.3390/children10030586.

Shared decision-making about medication intake during lactation: A prospective longitudinal study in Greece.

Tigka M, Metallinou D, Pardali L, Lykeridou K Eur J Midwifery. 2022; 6:48.

PMID: 35974713 PMC: 9340817. DOI: 10.18332/ejm/149830.

Self-Reported Medication Use among Pregnant and Breastfeeding Women during the COVID-19 Pandemic: A Cross-Sectional Study in Five European Countries.

Ceulemans M, Foulon V, Panchaud A, Winterfeld U, Pomar L, Lambelet V Int J Environ Res Public Health. 2022; 19(3).

PMID: 35162405 PMC: 8835534. DOI: 10.3390/ijerph19031389.

References

Rollins N, Bhandari N, Hajeebhoy N, Horton S, Lutter C, Martines J . Why invest, and what it will take to improve breastfeeding practices?. Lancet. 2016; 387(10017):491-504. DOI: 10.1016/S0140-6736(15)01044-2. View

Figueiredo B, Canario C, Field T . Breastfeeding is negatively affected by prenatal depression and reduces postpartum depression. Psychol Med. 2013; 44(5):927-36. DOI: 10.1017/S0033291713001530. View

McDonald K, Amir L, Davey M . Maternal bodies and medicines: a commentary on risk and decision-making of pregnant and breastfeeding women and health professionals. BMC Public Health. 2011; 11 Suppl 5:S5. PMC: 3247028. DOI: 10.1186/1471-2458-11-S5-S5. View

Horta B, Loret de Mola C, Victora C . Breastfeeding and intelligence: a systematic review and meta-analysis. Acta Paediatr. 2015; 104(467):14-9. DOI: 10.1111/apa.13139. View

Horta B, Loret de Mola C, Victora C . Long-term consequences of breastfeeding on cholesterol, obesity, systolic blood pressure and type 2 diabetes: a systematic review and meta-analysis. Acta Paediatr. 2015; 104(467):30-7. DOI: 10.1111/apa.13133. View

Chowdhury R, Sinha B, Sankar M, Taneja S, Bhandari N, Rollins N . Breastfeeding and maternal health outcomes: a systematic review and meta-analysis. Acta Paediatr. 2015; 104(467):96-113. PMC: 4670483. DOI: 10.1111/apa.13102. View

Rowe H, Baker T, Hale T . Maternal medication, drug use, and breastfeeding. Child Adolesc Psychiatr Clin N Am. 2014; 24(1):1-20. DOI: 10.1016/j.chc.2014.09.005. View

Hotham N, Hotham E . Drugs in breastfeeding. Aust Prescr. 2015; 38(5):156-9. PMC: 4657301. DOI: 10.18773/austprescr.2015.056. View

Lamounier J, Cabral C, Oliveira B, Oliveira A, Oliveira Jr A, Silva A . [Does drug therapy in the postpartum period interfere with breastfeeding recommendations?]. J Pediatr (Rio J). 2003; 78(1):57-61. View

10.

de Waard M, Blomjous B, Hol M, Sie S, Corpeleijn W, van Goudoever J . Medication Use During Pregnancy and Lactation in a Dutch Population. J Hum Lact. 2018; 35(1):154-164. DOI: 10.1177/0890334418775630. View

11.

Anderson P, Manoguerra A, Valdes V . A Review of Adverse Reactions in Infants From Medications in Breastmilk. Clin Pediatr (Phila). 2015; 55(3):236-44. DOI: 10.1177/0009922815594586. View

12.

Amir L, Ryan K, Jordan S . Avoiding risk at what cost? Putting use of medicines for breastfeeding women into perspective. Int Breastfeed J. 2012; 7(1):14. PMC: 3502159. DOI: 10.1186/1746-4358-7-14. View

13.

Hallal P, Bertoldi A, Domingues M, da Silveira M, Demarco F, da Silva I . Cohort Profile: The 2015 Pelotas (Brazil) Birth Cohort Study. Int J Epidemiol. 2017; 47(4):1048-1048h. PMC: 6124621. DOI: 10.1093/ije/dyx219. View

14.

Jayawickrama H, Amir L, Pirotta M . GPs' decision-making when prescribing medicines for breastfeeding women: Content analysis of a survey. BMC Res Notes. 2010; 3:82. PMC: 2860488. DOI: 10.1186/1756-0500-3-82. View

15.

Victora C, Bahl R, Barros A, Franca G, Horton S, Krasevec J . Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect. Lancet. 2016; 387(10017):475-90. DOI: 10.1016/S0140-6736(15)01024-7. View

16.

Saha M, Ryan K, Amir L . Postpartum women's use of medicines and breastfeeding practices: a systematic review. Int Breastfeed J. 2015; 10:28. PMC: 4625926. DOI: 10.1186/s13006-015-0053-6. View

17.

McClatchey A, Shield A, Cheong L, Ferguson S, Cooper G, Kyle G . Why does the need for medication become a barrier to breastfeeding? A narrative review. Women Birth. 2017; 31(5):362-366. DOI: 10.1016/j.wombi.2017.12.004. View

18.

Barros A, Hirakata V . Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio. BMC Med Res Methodol. 2003; 3:21. PMC: 521200. DOI: 10.1186/1471-2288-3-21. View

19.

Holmes A, Harris J, Ware S . Evaluation of Lactation Compatibility Reference Recommendations. Ann Pharmacother. 2019; 53(9):899-904. DOI: 10.1177/1060028019839389. View

20.

Ito S, Lee A . Drug excretion into breast milk--overview. Adv Drug Deliv Rev. 2003; 55(5):617-27. DOI: 10.1016/s0169-409x(03)00034-6. View