IgG4-related Disease with a Cardiac Mass

Overview

Journal Intern Med

Specialty General Medicine

Date 2020 Jan 21

PMID 31956206

Citations 6

Authors

Ikuko Matsumura

Takeki Mitsui

Kenichi Tahara

Hiroaki Shimizu

Kunio Yanagisawa

Takuma Ishizaki

Hiromi Koiso

Makiko Takizawa

Akihiko Yokohama

Takayuki Saitoh

Junko Hirato

Hirokazu Murakami

Hiroshi Handa

Norifumi Tsukamoto

Affiliations

Soon will be listed here.

Abstract

A 69-year-old man with palpitations and decreased blood pressure was referred. Echocardiography showed a mass in the right atrium and cardiac septum. The serum IgG4 level was 1,450 mg/dL. A biopsy of the cardiac mass showed fibrosis with inflammatory cells and increased IgG4-positive plasma cells and lymphocytes. Flow cytometry and polymerase chain reaction of the immunoglobulin heavy chain did not demonstrate monoclonality. He was diagnosed with IgG4-related disease (IgG4-RD). IgG4-RD with a cardiac mass is rare and it is difficult to distinguish it from malignant lymphoma by a pathological examination alone. We therefore performed a biopsy and analyzed the clonality in order to make an accurate diagnosis of IgG4-RD.

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