New Developments in Non-allergen-specific Therapy for the Treatment of Food Allergy

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2020 Jan 18

PMID 31950290

Citations 9

Authors

Andrew Long

Matteo Borro

Vanitha Sampath

R Sharon Chinthrajah

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: The prevalence of food allergy is increasing. At the current time, there are no approved treatments for food allergy. Major limitations of immunotherapy are long treatment periods (months or years), frequent clinic visits, high costs, increased risk of adverse events during treatment, and lack of durability of desensitization. Additionally, it is allergen-specific, and in those allergic to multiple allergens, the length and cost of treatment are further increased. In this review, we summarize recent developments in novel non-allergen-specific treatments for food allergy.

Recent Findings: A number of monoclonal antibodies that block IgE or specific pro-allergenic cytokines or their receptors have shown promise in clinical trials for food allergy. The insight we have gained through the use of one drug for the treatment of an atopic disease is quickly being translated to other atopic diseases, including food allergy. The future for food allergy treatment with biologics looks bright.

Citing Articles

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The rationale for development of ligelizumab in food allergy.

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Oral Immunotherapy in Children: Clinical Considerations and Practical Management.

Anderson B, Wong L, Adlou B, Long A, Chinthrajah R J Asthma Allergy. 2021; 14:1497-1510.

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References

Burks A, Sampson H, Plaut M, Lack G, Akdis C . Treatment for food allergy. J Allergy Clin Immunol. 2018; 141(1):1-9. DOI: 10.1016/j.jaci.2017.11.004. View

Fiocchi A, Artesani M, Riccardi C, Mennini M, Pecora V, Fierro V . Impact of Omalizumab on Food Allergy in Patients Treated for Asthma: A Real-Life Study. J Allergy Clin Immunol Pract. 2019; 7(6):1901-1909.e5. DOI: 10.1016/j.jaip.2019.01.023. View

Motosue M, Bellolio M, Van Houten H, Shah N, Campbell R . National trends in emergency department visits and hospitalizations for food-induced anaphylaxis in US children. Pediatr Allergy Immunol. 2018; 29(5):538-544. DOI: 10.1111/pai.12908. View

Takahashi M, Soejima K, Taniuchi S, Hatano Y, Yamanouchi S, Ishikawa H . Oral immunotherapy combined with omalizumab for high-risk cow's milk allergy: a randomized controlled trial. Sci Rep. 2017; 7(1):17453. PMC: 5727171. DOI: 10.1038/s41598-017-16730-6. View

Gri G, Piconese S, Frossi B, Manfroi V, Merluzzi S, Tripodo C . CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity. 2008; 29(5):771-81. PMC: 2590499. DOI: 10.1016/j.immuni.2008.08.018. View

Galand C, Leyva-Castillo J, Yoon J, Han A, Lee M, McKenzie A . IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J Allergy Clin Immunol. 2016; 138(5):1356-1366. PMC: 5099088. DOI: 10.1016/j.jaci.2016.03.056. View

. Dupilumab (Dupixent) for Asthma. JAMA. 2019; 321(10):1000-1001. DOI: 10.1001/jama.2019.0080. View

Leung D, Sampson H, Yunginger J, Burks Jr A, Schneider L, Wortel C . Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med. 2003; 348(11):986-93. DOI: 10.1056/NEJMoa022613. View

Fleischer D, Greenhawt M, Sussman G, Begin P, Nowak-Wegrzyn A, Petroni D . Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial. JAMA. 2019; 321(10):946-955. PMC: 6439674. DOI: 10.1001/jama.2019.1113. View

10.

Pellerin L, Jenks J, Chinthrajah S, Dominguez T, Block W, Zhou X . Peanut-specific type 1 regulatory T cells induced in vitro from allergic subjects are functionally impaired. J Allergy Clin Immunol. 2017; 141(1):202-213.e8. DOI: 10.1016/j.jaci.2017.05.045. View

11.

Divekar R, Kita H . Recent advances in epithelium-derived cytokines (IL-33, IL-25, and thymic stromal lymphopoietin) and allergic inflammation. Curr Opin Allergy Clin Immunol. 2014; 15(1):98-103. PMC: 4346181. DOI: 10.1097/ACI.0000000000000133. View

12.

Gupta R, Warren C, Smith B, Jiang J, Blumenstock J, Davis M . Prevalence and Severity of Food Allergies Among US Adults. JAMA Netw Open. 2019; 2(1):e185630. PMC: 6324316. DOI: 10.1001/jamanetworkopen.2018.5630. View

13.

Davies A, Allan E, Keeble A, Delgado J, Cossins B, Mitropoulou A . Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab. J Biol Chem. 2017; 292(24):9975-9987. PMC: 5473249. DOI: 10.1074/jbc.M117.776476. View

14.

Santos A, James L, Bahnson H, Shamji M, Couto-Francisco N, Islam S . IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens. J Allergy Clin Immunol. 2015; 135(5):1249-56. PMC: 4418748. DOI: 10.1016/j.jaci.2015.01.012. View

15.

Burton O, Medina Tamayo J, Stranks A, Miller S, Koleoglou K, Weinberg E . IgE promotes type 2 innate lymphoid cells in murine food allergy. Clin Exp Allergy. 2017; 48(3):288-296. PMC: 5828976. DOI: 10.1111/cea.13075. View

16.

Wright B, Kulis M, Orgel K, Burks A, Dawson P, Henning A . Component-resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsiveness. Allergy. 2016; 71(11):1552-1560. PMC: 5035709. DOI: 10.1111/all.12895. View

17.

Scurlock A . Oral and Sublingual Immunotherapy for Treatment of IgE-Mediated Food Allergy. Clin Rev Allergy Immunol. 2018; 55(2):139-152. DOI: 10.1007/s12016-018-8677-0. View

18.

Gauvreau G, OByrne P, Boulet L, Wang Y, Cockcroft D, Bigler J . Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 2014; 370(22):2102-10. DOI: 10.1056/NEJMoa1402895. View

19.

Nadeau K, Schneider L, Hoyte L, Borras I, Umetsu D . Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol. 2011; 127(6):1622-4. PMC: 3396422. DOI: 10.1016/j.jaci.2011.04.009. View

20.

Pattarini L, Trichot C, Bogiatzi S, Grandclaudon M, Meller S, Keuylian Z . TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand. J Exp Med. 2017; 214(5):1529-1546. PMC: 5413322. DOI: 10.1084/jem.20150402. View