High Expression of IL-1β and NFκB in Tumor Tissue Predicts a Low Recurrence Rate of Hepatocellular Carcinoma

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2020 Jan 18

PMID 31949688

Citations 1

Authors

Bangxu Yu

Aiqin Li

Mao Zhang

Haoran Li

Cheng Tao

Bing Han

Affiliations

Soon will be listed here.

Abstract

Objective: To study the relationship between interleukin (IL)-1β and nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) expressions in tumor tissue and the recurrence of hepatocellular carcinoma (HCC) after hepatectomy.

Methods: The expressions of IL-1β and NFκB in tumor tissues of 92 patients with HCC were measured using immunohistochemical staining. The correlations between IL-1β and NFκB expressions with clinical factors and postoperative recurrence were analyzed.

Results: Compared with the low expression group, the disease-free survival (DFS) of HCC with high expression of IL-1β and NFκB was more significantly prolonged (P < 0.05). NFκB is a key molecule in the downstream signaling pathway of IL-1β, and the expression of IL-1β and NFκB is positively associated with serum total bilirubin (TBIL). IL-1β and NFκB levels and platelet (PLT) levels were independent risk factors for postoperative recurrence of HCC (P < 0.05).

Conclusions: The low expressions of IL-1β and NFκB in HCC tissues are an independent risk factor for the recurrence of HCC after hepatectomy, but a high expression can significantly prolong DFS.

Citing Articles

Dynamic roles of inflammasomes in inflammatory tumor microenvironment.

Jang J, Kim D, Surh Y NPJ Precis Oncol. 2021; 5(1):18.

PMID: 33686176 PMC: 7940484. DOI: 10.1038/s41698-021-00154-7.

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