Effect of Vitamin D on Bone Strength in Older African Americans: a Randomized Controlled Trial

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2020 Jan 16

PMID 31938818

Citations 4

Authors

R Dhaliwal

S Islam

M Mikhail

L Ragolia

J F Aloia

Affiliations

Soon will be listed here.

Abstract

Introduction: The role of vitamin D in bone strength has not been investigated in the African American (AA) population.

Methods: A 3-year randomized controlled trial was designed to examine the effect of vitamin D supplementation on physical performance, bone loss, and bone strength in healthy older AA women. A total of 260 postmenopausal AA women, ages ≥ 60 years were randomized to a vitamin D or placebo arm. Vitamin D dose was adjusted to maintain serum 25OHD > 30 ng/mL. Bone mineral density, femoral axis length, and femoral neck (FN) width were measured by dual-energy X-ray absorptiometry. Composite indices of FN strength [compression strength index (CSI), bending strength index (BSI), and impact strength index (ISI)] were computed.

Results: The mean age of participants was 68.2 ± 4.9 years. Baseline characteristics between groups were similar. The average dose of vitamin D was 3490 ± 1465 IU/day in the active group. The mean serum 25OHD was 46.8 ± 1.2 ng/mL versus 20.7 ± 1.1 ng/mL in the active versus placebo group. Serum 25OHD did not correlate with any composite indices. The longitudinal differences observed in FN width, CSI, BSI, and ISI in both groups were not statistically significant (all p values > 0.05). Further, there was no group × time interaction effect for any of the composite indices (all p values > 0.05).

Conclusion: Maintaining serum 25OHD > 30 ng/mL (75 nmol/L) does not affect bone strength in older AA women. There is no evidence to support vitamin D intake greater than the recommended RDA by the Institute of Medicine in this population for bone strength.

Citing Articles

Effects of Isoflavonoid and Vitamin D Synergism on Bone Mineral Density-A Systematic and Critical Review.

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Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs.

Voulgaridou G, Papadopoulou S, Detopoulou P, Tsoumana D, Giaginis C, Kondyli F Diseases. 2023; 11(1).

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Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness and Molecular Mechanisms of Action During Accelerated Biological Aging.

Chen Y, Hamidu S, Yang X, Yan Y, Wang Q, Li L Front Genet. 2022; 13:880421.

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Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial.

Brahmbhatt S, Mikhail M, Islam S, Aloia J Nutrients. 2020; 12(3).

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