The Role of Macrophage Migration Inhibitory Factor in Alzheimer's Disease: Conventionally Pathogenetic or Unconventionally Protective?

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2020 Jan 16

PMID 31936865

Citations 22

Authors

Maria Cristina Petralia

Giuseppe Battaglia

Valeria Bruno

Manuela Pennisi

Katia Mangano

Salvo Danilo Lombardo

Paolo Fagone

Eugenio Cavalli

Andrea Saraceno

Ferdinando Nicoletti

Maria Sofia Basile

Affiliations

Soon will be listed here.

Abstract

Recent preclinical and clinical observations have offered relevant insights on the etiopathogenesis of late onset Alzheimer's disease (AD) and upregulated immunoinflammatory events have been described as underlying mechanisms involved in the development of AD. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by several cells of the innate and adaptive immune system, as well as non-immune cells. In the present review, we highlight experimental, genetic, and clinical studies on MIF in rodent models of AD and AD patients, and we discuss emerging therapeutic opportunities for tailored modulation of the activity of MIF, that may potentially be applied to AD patients. Dismantling the exact role of MIF and its receptors in AD may offer novel diagnostic and therapeutic opportunities in AD.

Citing Articles

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References

Sigurdsson E . Alzheimer's therapy development: A few points to consider. Prog Mol Biol Transl Sci. 2019; 168:205-217. DOI: 10.1016/bs.pmbts.2019.06.001. View

Liang C, Li J, Zhang Z, Zhang J, Liu S, Yang J . Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2018; 39(9):1421-1438. PMC: 6289349. DOI: 10.1038/aps.2017.210. View

Petralia M, Mazzon E, Fagone P, Basile M, Lenzo V, Quattropani M . Pathogenic contribution of the Macrophage migration inhibitory factor family to major depressive disorder and emerging tailored therapeutic approaches. J Affect Disord. 2019; 263:15-24. DOI: 10.1016/j.jad.2019.11.127. View

McManus R, Heneka M . Role of neuroinflammation in neurodegeneration: new insights. Alzheimers Res Ther. 2017; 9(1):14. PMC: 5336609. DOI: 10.1186/s13195-017-0241-2. View

Israelson A, Ditsworth D, Sun S, Song S, Liang J, Hruska-Plochan M . Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1. Neuron. 2015; 86(1):218-32. PMC: 4393372. DOI: 10.1016/j.neuron.2015.02.034. View

Oyama R, Yamamoto H, Titani K . Glutamine synthetase, hemoglobin alpha-chain, and macrophage migration inhibitory factor binding to amyloid beta-protein: their identification in rat brain by a novel affinity chromatography and in Alzheimer's disease brain by immunoprecipitation. Biochim Biophys Acta. 2000; 1479(1-2):91-102. DOI: 10.1016/s0167-4838(00)00057-1. View

Mehlhorn G, Hollborn M, Schliebs R . Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology. Int J Dev Neurosci. 2000; 18(4-5):423-31. DOI: 10.1016/s0736-5748(00)00012-5. View

Calandra T, Bucala R . Macrophage migration inhibitory factor (MIF): a glucocorticoid counter-regulator within the immune system. Crit Rev Immunol. 1997; 17(1):77-88. DOI: 10.1615/critrevimmunol.v17.i1.30. View

OReilly C, Doroudian M, Mawhinney L, Donnelly S . Targeting MIF in Cancer: Therapeutic Strategies, Current Developments, and Future Opportunities. Med Res Rev. 2016; 36(3):440-60. DOI: 10.1002/med.21385. View

10.

Popp J, Bacher M, Kolsch H, Noelker C, Deuster O, Dodel R . Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease. J Psychiatr Res. 2008; 43(8):749-53. DOI: 10.1016/j.jpsychires.2008.10.006. View

11.

Basile M, Mazzon E, Krajnovic T, Draca D, Cavalli E, Al-Abed Y . Anticancer and Differentiation Properties of the Nitric Oxide Derivative of Lopinavir in Human Glioblastoma Cells. Molecules. 2018; 23(10). PMC: 6222694. DOI: 10.3390/molecules23102463. View

12.

Martinez B, Peplow P . Amelioration of Alzheimer's disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer's disease. Neural Regen Res. 2019; 14(7):1158-1176. PMC: 6425849. DOI: 10.4103/1673-5374.251192. View

13.

Shin M, Kang Y, Wahl E, Park H, Lazova R, Leng L . Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex-Mediated Activation of the NLRP3 Inflammasome. Arthritis Rheumatol. 2018; 71(1):109-120. PMC: 6310104. DOI: 10.1002/art.40672. View

14.

Leyton-Jaimes M, Benaim C, Abu-Hamad S, Kahn J, Guetta A, Bucala R . Endogenous macrophage migration inhibitory factor reduces the accumulation and toxicity of misfolded SOD1 in a mouse model of ALS. Proc Natl Acad Sci U S A. 2016; 113(36):10198-203. PMC: 5018779. DOI: 10.1073/pnas.1604600113. View

15.

Bilsborrow J, Doherty E, Tilstam P, Bucala R . Macrophage migration inhibitory factor (MIF) as a therapeutic target for rheumatoid arthritis and systemic lupus erythematosus. Expert Opin Ther Targets. 2019; 23(9):733-744. PMC: 6800059. DOI: 10.1080/14728222.2019.1656718. View

16.

Webers A, Heneka M, Gleeson P . The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease. Immunol Cell Biol. 2019; 98(1):28-41. DOI: 10.1111/imcb.12301. View

17.

Lechien J, Nassri A, Kindt N, Brown D, Journe F, Saussez S . Role of macrophage migration inhibitory factor in head and neck cancer and novel therapeutic targets: A systematic review. Head Neck. 2017; 39(12):2573-2584. DOI: 10.1002/hed.24939. View

18.

Flex A, Pola R, Serricchio M, Gaetani E, Proia A, Di Giorgio A . Polymorphisms of the macrophage inhibitory factor and C-reactive protein genes in subjects with Alzheimer's dementia. Dement Geriatr Cogn Disord. 2004; 18(3-4):261-4. DOI: 10.1159/000080026. View

19.

Minter M, Taylor J, Crack P . The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease. J Neurochem. 2015; 136(3):457-74. DOI: 10.1111/jnc.13411. View

20.

Lane C, Hardy J, Schott J . Alzheimer's disease. Eur J Neurol. 2017; 25(1):59-70. DOI: 10.1111/ene.13439. View