Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2020 Jan 16

PMID 31936504

Citations 15

Authors

Andrei A Deviatkin

Yulia A Vakulenko

Ludmila V Akhmadishina

Vadim V Tarasov

Marina I Beloukhova

Andrey A Zamyatnin Jr

Alexander N Lukashev

Affiliations

Soon will be listed here.

Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory joint disease affecting about 1% of the population worldwide. Current treatment approaches do not ensure a cure for every patient. Moreover, classical regimens are based on nontargeted systemic immune suppression and have significant side effects. Biological treatment has advanced considerably but efficacy and specificity issues remain. Gene therapy is one of the potential future directions for RA therapy, which is rapidly developing. Several gene therapy trials done so far have been of moderate success, but experimental and genetics studies have yielded novel targets. As a result, the arsenal of gene therapy tools keeps growing. Currently, both viral and nonviral delivery systems are used for RA therapy. Herein, we review recent approaches for RA gene therapy.

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