Cortactin: A Major Cellular Target of the Gastric Carcinogen

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2020 Jan 16

PMID 31936446

Citations 10

Authors

Irshad Sharafutdinov

Steffen Backert

Nicole Tegtmeyer

Affiliations

Soon will be listed here.

Abstract

Cortactin is an actin binding protein and actin nucleation promoting factor regulating cytoskeletal rearrangements in nearly all eukaryotic cell types. From this perspective, cortactin poses an attractive target for pathogens to manipulate a given host cell to their own benefit. One of the pathogens following this strategy is , which can cause a variety of gastric diseases and has been shown to be the major risk factor for the onset of gastric cancer. During infection of gastric epithelial cells, hijacks the cellular kinase signaling pathways, leading to the disruption of key cell functions. Specifically, by overruling the phosphorylation status of cortactin, alternates the activity of molecular interaction partners of this important protein, thereby manipulating the performance of actin-cytoskeletal rearrangements and cell movement. In addition, utilizes a unique mechanism to activate focal adhesion kinase, which subsequently prevents host epithelial cells from extensive lifting from the extracellular matrix in order to achieve chronic infection in the human stomach.

Citing Articles

Cortactin-dependent control of Par1b-regulated epithelial cell polarity in infection.

Sharafutdinov I, Harrer A, Musken M, Rottner K, Sticht H, Tager C Cell Insight. 2024; 3(3):100161.

PMID: 38646547 PMC: 11033139. DOI: 10.1016/j.cellin.2024.100161.

Helicobacter pylori and Epstein-Barr virus infection in cell polarity alterations.

Baral B, Kandpal M, Ray A, Jana A, Yadav D, Sachin K Folia Microbiol (Praha). 2023; 69(1):41-57.

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Immunoinformatic prediction of potential immunodominant epitopes from cagW in order to investigate protection against Helicobacter pylori infection based on experimental consequences.

Chehelgerdi M, Heidarnia F, Dehkordi F, Chehelgerdi M, Khayati S, Khorramian-Ghahfarokhi M Funct Integr Genomics. 2023; 23(2):107.

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Prognosis of gastric adenocarcinoma associated with girdin, Akt, and cortactin.

Zhang Y, Liu C, Zhou L Ann Saudi Med. 2022; 42(3):181-190.

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Importance of cortactin for efficient epithelial NF-ĸB activation by Helicobacter pylori, Salmonella enterica and Pseudomonas aeruginosa, but not Campylobacter spp.

Tegtmeyer N, Soltan Esmaeili D, Sharafutdinov I, Knorr J, Naumann M, Alter T Eur J Microbiol Immunol (Bp). 2022; 11(4):95-103.

PMID: 35060920 PMC: 8830411. DOI: 10.1556/1886.2021.00023.

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