Associations of Severity of Fatty Liver with Oxidative Stress, SAA, CRP and Degree of Cerebral Arteriosclerosis in Cerebral Arteriosclerosis Patients Who Have Fatty Liver

Overview

Journal Int J Clin Exp Pathol

Specialty Pathology

Date 2020 Jan 15

PMID 31934140

Citations 2

Authors

Zengqiang Sun

Mingzhi Zhao

Wenwen Bian

Haifeng Ma

Chao Sun

Affiliations

Soon will be listed here.

Abstract

Objective: To analyze the associations of severity of fatty liver with oxidative stress, serum amyloid protein A (SAA), C-reactive protein (CRP) and degree of cerebral arteriosclerosis (CAS) in CAS patients with the complication of fatty liver, and to explore the predictive values of risk factors for these patients.

Methods: A total of 200 patients diagnosed with CAS in our hospital from October 2016 to November 2018 were selected, including 90 cases with fatty liver (observation group) and 110 cases without fatty liver (control group), and there were 123 males and 77 females. The general clinical data, liver function, oxidative stress status, inflammatory factor levels, and degree of CAS were compared between the two groups, and their correlations and influencing factors were explored.

Results: 1) There were no significant differences in the age, gender, and high-density lipoprotein (HDL) level between the observation group and control group (>0.05). The body mass index (BMI), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL) levels in the observation group were significantly higher than those in the control group. 2) The levels of liver function indexes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT), in the observation group were significantly higher than those in the control group, all (<0.05). 3) In terms of the oxidative stress, the level of malondialdehyde (MDA) in the observation group was higher than that in the control group, while the levels of superoxide dismutase (SOD) and glutathione (GSH) in the observation group were obviously lower than in the control group, all (<0.05). 4) The levels of inflammatory factors, including SAA, CRP and interleukin-6 (IL-6), in the observation group were much higher than those in the control group (<0.05). 5) Observation group had higher whole blood low shear viscosity, whole blood high shear viscosity, and plasma viscosity than the control group (<0.05). 6) ALT ( = 0.422, = 0.000) and SAA ( = 0.828, = 0.000) had positive correlations with the plasma viscosity, while GSH ( = -0.719, <0.001) had a negative correlation with the plasma viscosity.

Conclusion: The liver function index levels, oxidative stress status, and inflammatory factor levels in CAS patients may affect the severity of arteriosclerosis and fatty liver.

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