FGF Signaling Directs Myotube Guidance by Regulating Rac Activity

Overview

Journal Development

Specialty Biology

Date 2020 Jan 15

PMID 31932350

Citations 12

Authors

Shuo Yang

Allison Weske

Yingqiu Du

Juliana M Valera

Kenneth L Jones

Aaron N Johnson

Affiliations

Soon will be listed here.

Abstract

Nascent myotubes undergo a dramatic morphological transformation during myogenesis, in which the myotubes elongate over several cell diameters and are directed to the correct muscle attachment sites. Although this process of myotube guidance is essential to pattern the musculoskeletal system, the mechanisms that control myotube guidance remain poorly understood. Using transcriptomics, we found that components of the Fibroblast Growth Factor (FGF) signaling pathway were enriched in nascent myotubes in embryos. Null mutations in the FGF receptor (), or its ligands, caused significant myotube guidance defects. The FGF ligand Pyramus is expressed broadly in the ectoderm, and ectopic Pyramus expression disrupted muscle patterning. Mechanistically, Htl regulates the activity of Rho/Rac GTPases in nascent myotubes and effects changes in the actin cytoskeleton. FGF signals are thus essential regulators of myotube guidance that act through cytoskeletal regulatory proteins to pattern the musculoskeletal system.

Citing Articles

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