The Thalamocortical Circuit of Auditory Mismatch Negativity

Overview

Journal Biol Psychiatry

Publisher Elsevier

Specialty Psychiatry

Date 2020 Jan 12

PMID 31924325

Citations 29

Authors

Peter Lakatos

Monica N OConnell

Annamaria Barczak

Tammy McGinnis

Samuel Neymotin

Charles E Schroeder

John F Smiley

Daniel C Javitt

Affiliations

Soon will be listed here.

Abstract

Background: Mismatch negativity (MMN) is an extensively validated biomarker of cognitive function across both normative and clinical populations and has previously been localized to supratemporal auditory cortex. MMN is thought to represent a comparison of the features of the present stimulus versus a mnemonic template formed by the prior stimuli.

Methods: We used concurrent thalamic and primary auditory cortical (A1) laminar recordings in 7 macaques to evaluate the relative contributions of core (lemniscal) and matrix (nonlemniscal) thalamic afferents to MMN generation.

Results: We demonstrated that deviance-related activity is observed mainly in matrix regions of auditory thalamus, MMN generators are most prominent in layer 1 of cortex as opposed to sensory responses that activate layer 4 first and sequentially all cortical layers, and MMN is elicited independent of the frequency tuning of A1 neuronal ensembles. Consistent with prior reports, MMN-related thalamocortical activity was strongly inhibited by ketamine.

Conclusions: Taken together, our results demonstrate distinct matrix versus core thalamocortical circuitry underlying the generation of a higher-order brain response (MMN) versus sensory responses.

Citing Articles

Altered theta band and theta/beta ratio in mismatch negativity associate with treatment effect in schizophrenia with auditory hallucinations.

Guo Q, Zhao Z, Wang W, Hu X, Hu H, Hu Y Schizophr Res Cogn. 2025; 40:100344.

PMID: 39867752 PMC: 11764624. DOI: 10.1016/j.scog.2025.100344.

Predictive acoustical processing in human cortical layers.

Faes L, Zulfiqar I, Vizioli L, Yu Z, Wu Y, Shin J bioRxiv. 2025; .

PMID: 39829870 PMC: 11741426. DOI: 10.1101/2025.01.09.632099.

Mismatch Negativity (MMN) as a Pharmacodynamic/Response Biomarker for NMDA Receptor and Excitatory/Inhibitory Imbalance-Targeted Treatments in Schizophrenia.

Javitt D Adv Neurobiol. 2024; 40:411-451.

PMID: 39562453 DOI: 10.1007/978-3-031-69491-2_15.

Auditory Biomarkers of Neuropsychiatric Disorders in Nonhuman Primates.

OConnell M, Barczak A Adv Neurobiol. 2024; 40:219-234.

PMID: 39562447 DOI: 10.1007/978-3-031-69491-2_9.

EVIDENCE FOR AUDITORY STIMULUS-SPECIFIC ADAPTATION BUT NOT DEVIANCE DETECTION IN LARVAL ZEBRAFISH BRAINS.

Wilde M, Poulsen R, Qin W, Arnold J, Favre-Bulle I, Mattingley J bioRxiv. 2024; .

PMID: 38915708 PMC: 11195219. DOI: 10.1101/2024.06.14.597058.

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