Linkage Studies Do Not Confirm the Cytogenetic Location of Incontinentia Pigmenti on Xp11

Overview

Journal Hum Genet

Specialty Genetics

Date 1988 Nov 1

PMID 3192215

Citations 12

Authors

A Sefiani

D Sinnett

L Abel

S Heuertz

I Craig

N Fraser

T A Kruse

M Frydman

M O Peter

Affiliations

Soon will be listed here.

Abstract

Linkage studies have been performed in 5 incontinentia pigmenti (IP) families totaling 29 potentially informative meioses. Ten probes of the Xp arm were used, six of them were precisely localized on the X chromosome, using hamster X human somatic cell hybrids containing a broken X chromosome derived from an incontinentia pigmenti patient carrying an X;9 translocation [46,XX,t(X;9)(p11.21;q34)]. The following order for probes is proposed: pter - (DXS7, DXS146, DXS255) - IP1 - (DXS14, DXS90) - DXS106 - qter. The negative lod scores obtained exclude the possibility that in the families studied, the gene for IP is located in Xp11 or in the major part of the Xp arm.

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