A Genetic Signature Including Apolipoprotein Eε4 Potentiates the Risk of Herpes Simplex-associated Alzheimer's Disease

Overview

Journal Alzheimers Dement (N Y)

Date 2020 Jan 11

PMID 31921962

Citations 30

Authors

Karin Lopatko Lindman

Bodil Weidung

Jan Olsson

Maria Josefsson

Eloise Kok

Anders Johansson

Sture Eriksson

Goran Hallmans

Fredrik Elgh

Hugo Lovheim

Affiliations

Soon will be listed here.

Abstract

Introduction: Herpes simplex virus type 1 (HSV1) in combination with genetic susceptibility has previously been implicated in Alzheimer's disease (AD) pathogenesis.

Methods: Plasma from 360 AD cases, obtained on average 9.6 years before diagnosis, and their age- and sex-matched controls, were analyzed for anti-HSV1 immunoglobulin (Ig) G with enzyme-linked immunosorbent assays (ELISAs). genotype and nine other selected risk genes for AD were extracted from a genome-wide association study analysis by deCODE genetics, Reykjavik, Iceland.

Results: The interaction between 4 heterozygosity (24 or 3/4) and anti-HSV1 IgG carriage increased the risk of AD (OR 4.55, = .02). A genetic risk score based on the nine AD risk genes also interacted with anti-HSV1 IgG for the risk of developing AD (OR 2.35, = .01).

Discussion: The present findings suggest that the 4 allele and other AD genetic risk factors might potentiate the risk of HSV1-associated AD.

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