Effect of Chamomile on Chemotherapy-induced Neutropenia in Pediatric Leukemia Patients: A Randomized Triple-blind Placebo-controlled Clinical Trial

Overview

Journal Avicenna J Phytomed

Publisher Mashhad University of Medical Sciences

Date 2020 Jan 11

PMID 31921608

Citations 6

Authors

Babak Daneshfard

Mahdi Shahriari

Alireza Heiran

Majid Nimrouzi

Hassan Yarmohammadi

Affiliations

Soon will be listed here.

Abstract

Objective: Chemotherapy-induced neutropenia is one of the main side effects of acute lymphoblastic leukemia (ALL) treatment. In this trial, we evaluated the efficacy of chamomile in management of neutropenia.

Materials And Methods: This randomized triple-blind placebo-controlled clinical trial was carried out in 2-18-year-old children with ALL. Participants in each group daily received 2.5 ml of either chamomile syrup or placebo syrup for a period of 30 days. Participants' white blood cell (WBC), and absolute neutrophil count (ANC), as well as their quality of life were evaluated.

Results: The study was completed with a total of 40 patients. An increasing trend of ANC was observed in the treatment group despite the decreasing trend in placebo group, which was statistically significant between the two groups (P Interaction=0.019, 95% confidence intervals=15.076-171.324). No serious side effects were reported.

Conclusion: Using chamomile syrup as a complementary therapy in children with leukemia could improve their immunity (as it increased WBC) by minimizing chemotherapy-induced neutropenia.

Citing Articles

Management of Chemotherapy Side Effects in Childhood Leukemia: Persian Medicine Experience.

Daneshfard B, Jaladat A, Nimrouzi M Galen Med J. 2024; 12:e2926.

PMID: 38974135 PMC: 11227649. DOI: 10.31661/gmj.v12i0.2926.

Current use of medicinal plants for children's diseases among mothers in Southern Romania.

Petran M, Dragos D, Stoian I, Vlad A, Gilca M Front Pharmacol. 2024; 15:1377341.

PMID: 38841372 PMC: 11150775. DOI: 10.3389/fphar.2024.1377341.

Effect of lithium on chemotherapy-induced neutropenia in Egyptian breast cancer patients; a prospective clinical study.

ELKasar A, Hussien F, Abdel-Hamied H, Saleh I, Mahgoup E, El-Arabey A Cancer Chemother Pharmacol. 2024; 93(6):541-554.

PMID: 38324036 DOI: 10.1007/s00280-023-04620-w.

Effect of Chamomile on the Complications of Cancer: A Systematic Review.

Maleki M, Mardani A, Manouchehri M, Ashghali Farahani M, Vaismoradi M, Glarcher M Integr Cancer Ther. 2023; 22:15347354231164600.

PMID: 37052390 PMC: 10108427. DOI: 10.1177/15347354231164600.

Effectiveness of Acupuncture in Relieving Chemotherapy-induced Leukopenia in Patients With Breast Cancer: A Systematic Review With A Meta-Analysis and Trial Sequential Analysis.

Shih Y, Su J, Kung Y, Lin Y, To Anh D, Ridwan E Integr Cancer Ther. 2021; 20:15347354211063884.

PMID: 34930039 PMC: 8728772. DOI: 10.1177/15347354211063884.

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